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- W4313454070 abstract "Abstract Irritable bowel syndrome (IBS) is a global gastrointestinal disorder closely related to psychological stress exposure and local colonic inflammation. Herein, we investigated the effect of wrap‐restraint stress (WRS) on rat behavior, on adenosine monophosphate‐activated protein kinase–mammalian/mechanistic target of rapamycin–signal transducer and activator of transcription 3 (AMPK–mTOR–STAT3) signaling, and autophagy in colonic mucosa. The impact of chronic administration of vitamin D 3 and lactoferrin was compared. Twenty‐four male Wistar rats were randomly divided into four groups. Chronic WRS protocol was applied as a rodent model of IBS. Group I: naïve animals, Group II: WRS animals, Group III: WRS‐exposed and treated with vitamin D 3 (500 IU/kg/day), and Group IV: WRS‐exposed and treated with lactoferrin (300 mg/kg/day). In this study, we found that chronic administration of each of vitamin D 3 and lactoferrin resulted in a significant increase in social interaction test, interleukin‐10, AMPK, optical density of LC3B, goblet cell count and marked decrease in serum cortisol level, STAT3, inflammatory cell count, and optical density of mTOR in comparison to the WRS rats. Our findings suggest that both vitamin D 3 and Lactoferrin could augment colonic autophagy through enhanced AMPK expression and inhibition of mTOR–STAT3 signaling, which offers practical insights into their clinical use in the prevention and therapy of IBS. However, lactoferrin intake as a nutritional supplement could be more helpful for stress‐induced colitis treatment than vitamin D 3." @default.
- W4313454070 created "2023-01-06" @default.
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- W4313454070 date "2023-01-01" @default.
- W4313454070 modified "2023-09-26" @default.
- W4313454070 title "Vitamin D and lactoferrin attenuate stress‐induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR–STAT3 signaling and modulating autophagy" @default.
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- W4313454070 cites W2001568034 @default.
- W4313454070 cites W2008062089 @default.
- W4313454070 cites W2008267385 @default.
- W4313454070 cites W2014548509 @default.
- W4313454070 cites W2017020557 @default.
- W4313454070 cites W2020920210 @default.
- W4313454070 cites W2022633707 @default.
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- W4313454070 cites W2048527621 @default.
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- W4313454070 cites W2084882106 @default.
- W4313454070 cites W2085563796 @default.
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- W4313454070 cites W2320204828 @default.
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- W4313454070 cites W2476257418 @default.
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- W4313454070 doi "https://doi.org/10.1002/cbf.3774" @default.
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