FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454080> ?p ?o ?g. }

• W4313454080 abstract "Sponsors often rely on multi-regional clinical trials (MRCTs) to introduce new treatments more rapidly into the global market. Many commonly used statistical methods do not account for regional differences, and small regional sample sizes frequently result in lower estimation quality of region-specific treatment effects. The International Council for Harmonization E17 guidelines suggest consideration of methods that allow for information borrowing across regions to improve estimation. In response to these guidelines, we develop a novel methodology to estimate global and region-specific treatment effects from MRCTs with time-to-event endpoints using Bayesian model averaging (BMA). This approach accounts for the possibility of heterogeneous treatment effects between regions, and we discuss how to assess the consistency of these effects using posterior model probabilities. We obtain posterior samples of the treatment effects using a Laplace approximation, and we show through simulation studies that the proposed modeling approach estimates region-specific treatment effects with lower mean squared error than a Cox proportional hazards model while resulting in a similar rejection rate of the global treatment effect. We then apply the BMA approach to data from the LEADER trial, an MRCT designed to evaluate the cardiovascular safety of an anti-diabetic treatment." @default.
• W4313454080 created "2023-01-06" @default.
• W4313454080 creator A5051097761 @default.
• W4313454080 creator A5056185563 @default.
• W4313454080 creator A5078399867 @default.
• W4313454080 date "2023-01-12" @default.
• W4313454080 modified "2023-10-13" @default.
• W4313454080 title "Bayesian design of multi‐regional clinical trials with time‐to‐event endpoints" @default.
• W4313454080 cites W1536497620 @default.
• W4313454080 cites W1603903339 @default.
• W4313454080 cites W1860392020 @default.
• W4313454080 cites W1968661639 @default.
• W4313454080 cites W1978129804 @default.
• W4313454080 cites W1980801068 @default.
• W4313454080 cites W1981457167 @default.
• W4313454080 cites W2000032254 @default.
• W4313454080 cites W2017696952 @default.
• W4313454080 cites W2065532917 @default.
• W4313454080 cites W2069429561 @default.
• W4313454080 cites W2106982838 @default.
• W4313454080 cites W2144898279 @default.
• W4313454080 cites W2425644022 @default.
• W4313454080 cites W2492359674 @default.
• W4313454080 cites W2560833249 @default.
• W4313454080 cites W2789818596 @default.
• W4313454080 cites W2804695567 @default.
• W4313454080 cites W2901718970 @default.
• W4313454080 cites W2945159125 @default.
• W4313454080 cites W2963819698 @default.
• W4313454080 cites W3005541333 @default.
• W4313454080 cites W3116398452 @default.
• W4313454080 cites W3172174238 @default.
• W4313454080 cites W3184751725 @default.
• W4313454080 cites W3215745400 @default.
• W4313454080 cites W4211177544 @default.
• W4313454080 cites W4252722076 @default.
• W4313454080 cites W4293738259 @default.
• W4313454080 cites W566543047 @default.
• W4313454080 doi "https://doi.org/10.1111/biom.13820" @default.
• W4313454080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36594642" @default.
• W4313454080 hasPublicationYear "2023" @default.
• W4313454080 type Work @default.
• W4313454080 citedByCount "2" @default.
• W4313454080 countsByYear W43134540802023 @default.
• W4313454080 crossrefType "journal-article" @default.
• W4313454080 hasAuthorship W4313454080A5051097761 @default.
• W4313454080 hasAuthorship W4313454080A5056185563 @default.
• W4313454080 hasAuthorship W4313454080A5078399867 @default.
• W4313454080 hasConcept C105795698 @default.
• W4313454080 hasConcept C107673813 @default.
• W4313454080 hasConcept C121332964 @default.
• W4313454080 hasConcept C129848803 @default.
• W4313454080 hasConcept C142724271 @default.
• W4313454080 hasConcept C149782125 @default.
• W4313454080 hasConcept C154945302 @default.
• W4313454080 hasConcept C22243797 @default.
• W4313454080 hasConcept C24890656 @default.
• W4313454080 hasConcept C2776436953 @default.
• W4313454080 hasConcept C2779662365 @default.
• W4313454080 hasConcept C2779962950 @default.
• W4313454080 hasConcept C2987370644 @default.
• W4313454080 hasConcept C33923547 @default.
• W4313454080 hasConcept C41008148 @default.
• W4313454080 hasConcept C535046627 @default.
• W4313454080 hasConcept C556039675 @default.
• W4313454080 hasConcept C62520636 @default.
• W4313454080 hasConcept C71924100 @default.
• W4313454080 hasConceptScore W4313454080C105795698 @default.
• W4313454080 hasConceptScore W4313454080C107673813 @default.
• W4313454080 hasConceptScore W4313454080C121332964 @default.
• W4313454080 hasConceptScore W4313454080C129848803 @default.
• W4313454080 hasConceptScore W4313454080C142724271 @default.
• W4313454080 hasConceptScore W4313454080C149782125 @default.
• W4313454080 hasConceptScore W4313454080C154945302 @default.
• W4313454080 hasConceptScore W4313454080C22243797 @default.
• W4313454080 hasConceptScore W4313454080C24890656 @default.
• W4313454080 hasConceptScore W4313454080C2776436953 @default.
• W4313454080 hasConceptScore W4313454080C2779662365 @default.
• W4313454080 hasConceptScore W4313454080C2779962950 @default.
• W4313454080 hasConceptScore W4313454080C2987370644 @default.
• W4313454080 hasConceptScore W4313454080C33923547 @default.
• W4313454080 hasConceptScore W4313454080C41008148 @default.
• W4313454080 hasConceptScore W4313454080C535046627 @default.
• W4313454080 hasConceptScore W4313454080C556039675 @default.
• W4313454080 hasConceptScore W4313454080C62520636 @default.
• W4313454080 hasConceptScore W4313454080C71924100 @default.
• W4313454080 hasFunder F4320337361 @default.
• W4313454080 hasLocation W43134540801 @default.
• W4313454080 hasLocation W43134540802 @default.
• W4313454080 hasOpenAccess W4313454080 @default.
• W4313454080 hasPrimaryLocation W43134540801 @default.
• W4313454080 hasRelatedWork W1637985398 @default.
• W4313454080 hasRelatedWork W1896167979 @default.
• W4313454080 hasRelatedWork W2002288054 @default.
• W4313454080 hasRelatedWork W2015043718 @default.
• W4313454080 hasRelatedWork W2049379047 @default.
• W4313454080 hasRelatedWork W2289580157 @default.
• W4313454080 hasRelatedWork W2555213952 @default.
• W4313454080 hasRelatedWork W2946579579 @default.
• W4313454080 hasRelatedWork W3145231964 @default.

• next