Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454302> ?p ?o ?g. }
- W4313454302 endingPage "121284" @default.
- W4313454302 startingPage "121284" @default.
- W4313454302 abstract "Cardiorespiratory fitness (CRF), an important biomarker of human health, is impaired in cold environment compared to thermoneutral condition. The study aimed to investigate the role of metabolome response to acute exercise in regulation of CRF at different ambient temperatures. A total of 27 young adults were recruited, and each subject underwent a cardiopulmonary exercise test (CPET) and a constant load submaximal exercise at both room temperature (25 °C) and cold temperature (0 °C). The serum samples were collected before and immediately after constant load exercise. Acute cold exposure decreased CRF by 41 %, accompanied by a metabolic shift to anaerobic respiration. It also decreased VO2 and increased respiratory quotient during constant load exercise. Metabolome profiling revealed that acute exercise reprogrammed serum metabolome in an ambient temperature-dependent manner. Specifically, exercise increased a cluster of fatty acids during cold exposure, possibly due to impaired fatty acid oxidation. The correlations between metabolite responses to acute exercise and exercise parameters were analyzed using partial least squares regression and machine learning, revealing that metabolite responses to acute exercise were highly correlated with exercise parameters and predictive of CRF. Among the contributors, tryptophan and its metabolites stood out as important ones. These results suggested that the metabolite responses to acute submaximal exercise unmasks the exercise performance at different ambient temperatures, highlighting the role of metabolite orchestration in the physiological regulation of CRF." @default.
- W4313454302 created "2023-01-06" @default.
- W4313454302 creator A5007050536 @default.
- W4313454302 creator A5007133338 @default.
- W4313454302 creator A5010851175 @default.
- W4313454302 creator A5024255536 @default.
- W4313454302 creator A5039002588 @default.
- W4313454302 creator A5050705235 @default.
- W4313454302 creator A5052024256 @default.
- W4313454302 creator A5055115466 @default.
- W4313454302 creator A5060102665 @default.
- W4313454302 creator A5061215099 @default.
- W4313454302 creator A5069559397 @default.
- W4313454302 creator A5070888564 @default.
- W4313454302 creator A5071161888 @default.
- W4313454302 creator A5072686480 @default.
- W4313454302 creator A5083371430 @default.
- W4313454302 date "2023-01-01" @default.
- W4313454302 modified "2023-10-18" @default.
- W4313454302 title "Temperature-dependent metabolite orchestration to acute submaximal exercise indicates cardiorespiratory fitness in humans" @default.
- W4313454302 cites W1495741974 @default.
- W4313454302 cites W1982398730 @default.
- W4313454302 cites W1984681626 @default.
- W4313454302 cites W2002980117 @default.
- W4313454302 cites W2005414614 @default.
- W4313454302 cites W2018336180 @default.
- W4313454302 cites W2043819037 @default.
- W4313454302 cites W2051033597 @default.
- W4313454302 cites W2065389174 @default.
- W4313454302 cites W2074602210 @default.
- W4313454302 cites W2084734325 @default.
- W4313454302 cites W2086562954 @default.
- W4313454302 cites W2106345877 @default.
- W4313454302 cites W2163162924 @default.
- W4313454302 cites W2202803087 @default.
- W4313454302 cites W2408155307 @default.
- W4313454302 cites W2555189237 @default.
- W4313454302 cites W2598024881 @default.
- W4313454302 cites W2619635692 @default.
- W4313454302 cites W2734690070 @default.
- W4313454302 cites W2741302852 @default.
- W4313454302 cites W2782462798 @default.
- W4313454302 cites W2784032956 @default.
- W4313454302 cites W2800024870 @default.
- W4313454302 cites W2807728333 @default.
- W4313454302 cites W2809134706 @default.
- W4313454302 cites W2904219070 @default.
- W4313454302 cites W2911968308 @default.
- W4313454302 cites W2986040645 @default.
- W4313454302 cites W2991222734 @default.
- W4313454302 cites W3013937221 @default.
- W4313454302 cites W3029490310 @default.
- W4313454302 cites W3044060299 @default.
- W4313454302 cites W3081342845 @default.
- W4313454302 cites W3085021865 @default.
- W4313454302 cites W3086698680 @default.
- W4313454302 cites W3107083588 @default.
- W4313454302 cites W3112407022 @default.
- W4313454302 cites W3117184333 @default.
- W4313454302 cites W3119971140 @default.
- W4313454302 cites W3142605790 @default.
- W4313454302 cites W3171540867 @default.
- W4313454302 cites W3202884287 @default.
- W4313454302 cites W3210956039 @default.
- W4313454302 cites W3212098597 @default.
- W4313454302 cites W3213366336 @default.
- W4313454302 cites W3214503693 @default.
- W4313454302 cites W3214543657 @default.
- W4313454302 cites W3216734109 @default.
- W4313454302 cites W4213289846 @default.
- W4313454302 cites W4225911871 @default.
- W4313454302 cites W4280503603 @default.
- W4313454302 cites W4282972916 @default.
- W4313454302 cites W4283367198 @default.
- W4313454302 cites W4285796198 @default.
- W4313454302 cites W4288455565 @default.
- W4313454302 cites W4289223918 @default.
- W4313454302 doi "https://doi.org/10.1016/j.lfs.2022.121284" @default.
- W4313454302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36529280" @default.
- W4313454302 hasPublicationYear "2023" @default.
- W4313454302 type Work @default.
- W4313454302 citedByCount "1" @default.
- W4313454302 countsByYear W43134543022023 @default.
- W4313454302 crossrefType "journal-article" @default.
- W4313454302 hasAuthorship W4313454302A5007050536 @default.
- W4313454302 hasAuthorship W4313454302A5007133338 @default.
- W4313454302 hasAuthorship W4313454302A5010851175 @default.
- W4313454302 hasAuthorship W4313454302A5024255536 @default.
- W4313454302 hasAuthorship W4313454302A5039002588 @default.
- W4313454302 hasAuthorship W4313454302A5050705235 @default.
- W4313454302 hasAuthorship W4313454302A5052024256 @default.
- W4313454302 hasAuthorship W4313454302A5055115466 @default.
- W4313454302 hasAuthorship W4313454302A5060102665 @default.
- W4313454302 hasAuthorship W4313454302A5061215099 @default.
- W4313454302 hasAuthorship W4313454302A5069559397 @default.
- W4313454302 hasAuthorship W4313454302A5070888564 @default.
- W4313454302 hasAuthorship W4313454302A5071161888 @default.
- W4313454302 hasAuthorship W4313454302A5072686480 @default.