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- W4313454313 endingPage "526" @default.
- W4313454313 startingPage "502" @default.
- W4313454313 abstract "Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell cancer characterized by unbridled proliferation of malignant marrow stem cells with associated infection, anemia, and bleeding. An improved understanding of pathophysiology, improvements in measurement technology and at least 10 recently approved therapies have led to revamping the diagnostic, prognostic, and therapeutic landscape of AML.One updated and one new classification system were published in 2022, both emphasizing the integration of molecular analysis into daily practice. Differences between the International Consensus Classification and major revisions from the previous 2016 WHO system provide both challenges and opportunities for care and clinical research.The European Leukemia Net 2022 risk classification integrates knowledge from novel molecular findings and recent trial results, as well as emphasizing dynamic risk based on serial measurable residual disease assessment. However, how to leverage our burgeoning ability to measure a small number of potentially malignant myeloid cells into therapeutic decision making is controversial.The diagnostic and therapeutic complexity plus the availability of newly approved agents requires a nuanced therapeutic algorithm which should integrate patient goals of care, comorbidities, and disease characteristics including the specific mutational profile of the patient's AML. The framework we suggest only represents the beginning of the discussion." @default.
- W4313454313 created "2023-01-06" @default.
- W4313454313 creator A5013969487 @default.
- W4313454313 creator A5049059619 @default.
- W4313454313 creator A5071023119 @default.
- W4313454313 date "2023-01-13" @default.
- W4313454313 modified "2023-09-30" @default.
- W4313454313 title "Acute myeloid leukemia: 2023 update on diagnosis, risk‐stratification, and management" @default.
- W4313454313 cites W1580063028 @default.
- W4313454313 cites W1600365609 @default.
- W4313454313 cites W1622548798 @default.
- W4313454313 cites W1804439365 @default.
- W4313454313 cites W1857665725 @default.
- W4313454313 cites W1948328750 @default.
- W4313454313 cites W1974804829 @default.
- W4313454313 cites W1975730466 @default.
- W4313454313 cites W1977917277 @default.
- W4313454313 cites W1987746106 @default.
- W4313454313 cites W1996100864 @default.
- W4313454313 cites W1999922837 @default.
- W4313454313 cites W2007386979 @default.
- W4313454313 cites W2013923593 @default.
- W4313454313 cites W2025086811 @default.
- W4313454313 cites W2026826794 @default.
- W4313454313 cites W2032494548 @default.
- W4313454313 cites W2033857851 @default.
- W4313454313 cites W2052690356 @default.
- W4313454313 cites W2054634308 @default.
- W4313454313 cites W2058188142 @default.
- W4313454313 cites W2069448515 @default.
- W4313454313 cites W2074425311 @default.
- W4313454313 cites W2078972833 @default.
- W4313454313 cites W2079025304 @default.
- W4313454313 cites W2082646723 @default.
- W4313454313 cites W2084219839 @default.
- W4313454313 cites W2086693026 @default.
- W4313454313 cites W2092668959 @default.
- W4313454313 cites W2097192169 @default.
- W4313454313 cites W2102375783 @default.
- W4313454313 cites W2102461774 @default.
- W4313454313 cites W2103746815 @default.
- W4313454313 cites W2106084333 @default.
- W4313454313 cites W2107027906 @default.
- W4313454313 cites W2109948637 @default.
- W4313454313 cites W2118270328 @default.
- W4313454313 cites W2122587491 @default.
- W4313454313 cites W2127568389 @default.
- W4313454313 cites W2129338773 @default.
- W4313454313 cites W2130318943 @default.
- W4313454313 cites W2134061682 @default.
- W4313454313 cites W2137881702 @default.
- W4313454313 cites W2146862320 @default.
- W4313454313 cites W2148883973 @default.
- W4313454313 cites W2153310476 @default.
- W4313454313 cites W2154218976 @default.
- W4313454313 cites W2159746057 @default.
- W4313454313 cites W2161938647 @default.
- W4313454313 cites W2170510628 @default.
- W4313454313 cites W2173773534 @default.
- W4313454313 cites W2184458350 @default.
- W4313454313 cites W2205886515 @default.
- W4313454313 cites W2252789948 @default.
- W4313454313 cites W2276580523 @default.
- W4313454313 cites W2277044564 @default.
- W4313454313 cites W2330718732 @default.
- W4313454313 cites W2339658711 @default.
- W4313454313 cites W2419140434 @default.
- W4313454313 cites W2465734185 @default.
- W4313454313 cites W2474389367 @default.
- W4313454313 cites W2558945204 @default.
- W4313454313 cites W2559537906 @default.
- W4313454313 cites W2561289538 @default.
- W4313454313 cites W2623089849 @default.
- W4313454313 cites W2624542822 @default.
- W4313454313 cites W2654449699 @default.
- W4313454313 cites W2715749014 @default.
- W4313454313 cites W2733429355 @default.
- W4313454313 cites W2783500974 @default.
- W4313454313 cites W2794480810 @default.
- W4313454313 cites W2798041034 @default.
- W4313454313 cites W2800327377 @default.
- W4313454313 cites W2802609999 @default.
- W4313454313 cites W2804780558 @default.
- W4313454313 cites W2805058565 @default.
- W4313454313 cites W2806682325 @default.
- W4313454313 cites W2808694334 @default.
- W4313454313 cites W2808807711 @default.
- W4313454313 cites W2880011386 @default.
- W4313454313 cites W2883399820 @default.
- W4313454313 cites W2892736736 @default.
- W4313454313 cites W2895135050 @default.
- W4313454313 cites W2904378474 @default.
- W4313454313 cites W2905344869 @default.
- W4313454313 cites W2922692686 @default.
- W4313454313 cites W2943740528 @default.
- W4313454313 cites W2946312419 @default.
- W4313454313 cites W2952209878 @default.
- W4313454313 cites W2961401803 @default.