FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454367> ?p ?o ?g. }

• W4313454367 abstract "In-source fragmentation (ISF) is a naturally occurring phenomenon in various ion sources including soft ionization techniques such as matrix-assisted laser desorption/ionization (MALDI). It has traditionally been minimized as it makes the dataset more complex and often leads to mis-annotation of metabolites. Here, we introduce an approach termed PICA (for pixel intensity correlation analysis) that takes advantage of ISF in MALDI imaging to increase confidence in metabolite identification. In PICA, the extraction and association of in-source fragments to their precursor ion results in “pseudo-MS/MS spectra” that can be used for identification. We examined PICA using three different datasets, two of which were published previously and included validated metabolites annotation. We show that highly colocalized ions possessing Pearson correlation coefficient (PCC) ≥ 0.9 for a given precursor ion are mainly its in-source fragments, natural isotopes, adduct ions, or multimers. These ions provide rich information for their precursor ion identification. In addition, our results show that moderately colocalized ions (PCC < 0.9) may be structurally related to the precursor ion, which allows for the identification of unknown metabolites through known ones. Finally, we propose three strategies to reduce the total computation time for PICA in MALDI imaging. To conclude, PICA provides an efficient approach to extract and group ions stemming from the same metabolites in MALDI imaging and thus allows for high-confidence metabolite identification." @default.
• W4313454367 created "2023-01-06" @default.
• W4313454367 creator A5002431398 @default.
• W4313454367 creator A5003834811 @default.
• W4313454367 creator A5006511652 @default.
• W4313454367 creator A5013335542 @default.
• W4313454367 creator A5026316454 @default.
• W4313454367 creator A5069547114 @default.
• W4313454367 date "2023-01-03" @default.
• W4313454367 modified "2023-09-23" @default.
• W4313454367 title "PICA: Pixel Intensity Correlation Analysis for Deconvolution and Metabolite Identification in Mass Spectrometry Imaging" @default.
• W4313454367 cites W1511445613 @default.
• W4313454367 cites W1611854178 @default.
• W4313454367 cites W1914304737 @default.
• W4313454367 cites W1963646232 @default.
• W4313454367 cites W1972329860 @default.
• W4313454367 cites W1983866519 @default.
• W4313454367 cites W2009283470 @default.
• W4313454367 cites W2019231695 @default.
• W4313454367 cites W2020430110 @default.
• W4313454367 cites W2039920286 @default.
• W4313454367 cites W2106855677 @default.
• W4313454367 cites W2115507180 @default.
• W4313454367 cites W2122669551 @default.
• W4313454367 cites W2123607611 @default.
• W4313454367 cites W2150737519 @default.
• W4313454367 cites W2152179239 @default.
• W4313454367 cites W2154316868 @default.
• W4313454367 cites W2167792766 @default.
• W4313454367 cites W2283079346 @default.
• W4313454367 cites W2289368401 @default.
• W4313454367 cites W2325790065 @default.
• W4313454367 cites W2346249063 @default.
• W4313454367 cites W2553654192 @default.
• W4313454367 cites W2612998279 @default.
• W4313454367 cites W2739064330 @default.
• W4313454367 cites W2758152277 @default.
• W4313454367 cites W2765207987 @default.
• W4313454367 cites W2770676323 @default.
• W4313454367 cites W2785967221 @default.
• W4313454367 cites W2804360210 @default.
• W4313454367 cites W2885755945 @default.
• W4313454367 cites W2888724956 @default.
• W4313454367 cites W2904868445 @default.
• W4313454367 cites W2911591993 @default.
• W4313454367 cites W2921601813 @default.
• W4313454367 cites W2936056898 @default.
• W4313454367 cites W2940558238 @default.
• W4313454367 cites W2985897872 @default.
• W4313454367 cites W2998799555 @default.
• W4313454367 cites W3014710114 @default.
• W4313454367 cites W3041911784 @default.
• W4313454367 cites W3088009906 @default.
• W4313454367 cites W3091047196 @default.
• W4313454367 cites W3178763917 @default.
• W4313454367 cites W3181660183 @default.
• W4313454367 cites W4283388267 @default.
• W4313454367 doi "https://doi.org/10.1021/acs.analchem.2c04778" @default.
• W4313454367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36594613" @default.
• W4313454367 hasPublicationYear "2023" @default.
• W4313454367 type Work @default.
• W4313454367 citedByCount "2" @default.
• W4313454367 countsByYear W43134543672023 @default.
• W4313454367 crossrefType "journal-article" @default.
• W4313454367 hasAuthorship W4313454367A5002431398 @default.
• W4313454367 hasAuthorship W4313454367A5003834811 @default.
• W4313454367 hasAuthorship W4313454367A5006511652 @default.
• W4313454367 hasAuthorship W4313454367A5013335542 @default.
• W4313454367 hasAuthorship W4313454367A5026316454 @default.
• W4313454367 hasAuthorship W4313454367A5069547114 @default.
• W4313454367 hasBestOaLocation W43134543671 @default.
• W4313454367 hasConcept C111919701 @default.
• W4313454367 hasConcept C113196181 @default.
• W4313454367 hasConcept C145148216 @default.
• W4313454367 hasConcept C150394285 @default.
• W4313454367 hasConcept C162356407 @default.
• W4313454367 hasConcept C162711632 @default.
• W4313454367 hasConcept C178790620 @default.
• W4313454367 hasConcept C185592680 @default.
• W4313454367 hasConcept C191015642 @default.
• W4313454367 hasConcept C2777477808 @default.
• W4313454367 hasConcept C41008148 @default.
• W4313454367 hasConcept C43617362 @default.
• W4313454367 hasConcept C55493867 @default.
• W4313454367 hasConcept C75280812 @default.
• W4313454367 hasConceptScore W4313454367C111919701 @default.
• W4313454367 hasConceptScore W4313454367C113196181 @default.
• W4313454367 hasConceptScore W4313454367C145148216 @default.
• W4313454367 hasConceptScore W4313454367C150394285 @default.
• W4313454367 hasConceptScore W4313454367C162356407 @default.
• W4313454367 hasConceptScore W4313454367C162711632 @default.
• W4313454367 hasConceptScore W4313454367C178790620 @default.
• W4313454367 hasConceptScore W4313454367C185592680 @default.
• W4313454367 hasConceptScore W4313454367C191015642 @default.
• W4313454367 hasConceptScore W4313454367C2777477808 @default.
• W4313454367 hasConceptScore W4313454367C41008148 @default.
• W4313454367 hasConceptScore W4313454367C43617362 @default.
• W4313454367 hasConceptScore W4313454367C55493867 @default.
• W4313454367 hasConceptScore W4313454367C75280812 @default.
• W4313454367 hasFunder F4320323706 @default.

• next