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- W4313454705 endingPage "096368972211449" @default.
- W4313454705 startingPage "096368972211449" @default.
- W4313454705 abstract "Aptamers are single-stranded nucleic acids (DNA, short RNA, or other artificial molecules) produced by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology, which can be tightly and specifically combined with desired targets. As a comparable alternative to antibodies, aptamers have many advantages over traditional antibodies such as a strong chemical stability and rapid bulk production. In addition, aptamers can bind targets in various ways, and are not limited like the antigen-antibody combination. Studies have shown that aptamers have tremendous potential to diagnose and treat clinical diseases. However, only a few aptamer-based drugs have been used because of limitations of the aptamers and SELEX technology. To promote the development and applications of aptamers, we present a review of the methods optimizing the SELEX technology and modifying aptamers to boost the selection success rate and improve aptamer characteristics. In addition, we review the application of aptamers to treat bone diseases." @default.
- W4313454705 created "2023-01-06" @default.
- W4313454705 creator A5007918060 @default.
- W4313454705 creator A5010571447 @default.
- W4313454705 creator A5019457778 @default.
- W4313454705 creator A5053385426 @default.
- W4313454705 creator A5054217323 @default.
- W4313454705 creator A5064903485 @default.
- W4313454705 creator A5086807774 @default.
- W4313454705 creator A5087332244 @default.
- W4313454705 date "2023-01-01" @default.
- W4313454705 modified "2023-09-27" @default.
- W4313454705 title "Aptamer Technology and Its Applications in Bone Diseases" @default.
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