FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454744> ?p ?o ?g. }

• W4313454744 endingPage "121352" @default.
• W4313454744 startingPage "121352" @default.
• W4313454744 abstract "Traumatic brain injury (TBI), an acquired brain injury imparted by a mechanical trauma to the head, has significant ramifications in terms of long-term disability and cost of healthcare. TBI is characterized by an initial phase of cell death owing to direct mechanical injury, followed by a secondary phase in which neuroinflammation plays a pivotal role. Activation of inflammasome complexes triggers a cascade that leads to activation of inflammatory mediators such as caspase-1, Interleukin (IL)-18, and IL-1β, eventually causing pyroptosis. NLRP3 inflammasome, a component of the innate immune response, has been implicated in a number of neurodegenerative diseases, including TBI. Recent findings indicate that NLRP3 inhibitors can potentially ameliorate neuroinflammation and improve cognition and motor function in TBI. The NLRP3 inflammasome also holds potential as a predictive biomarker for the long-term sequelae following TBI. Although several therapeutic agents have shown promising results in pre-clinical studies, none of them have been effective in human trials for TBI, to date. Thus, it is imperative that such promising therapeutic candidates are evaluated in clinical trials to assess their efficacy in alleviating neurological impairments in TBI. This review offers an insight into the pathophysiology of TBI, with an emphasis on neuroinflammation in the aftermath of TBI. We highlight the NLRP3 inflammasome and explore its role in the neuroinflammatory cascade in TBI. We also shed light on its potential as a prospective biomarker and therapeutic target for TBI management." @default.
• W4313454744 created "2023-01-06" @default.
• W4313454744 creator A5031953015 @default.
• W4313454744 creator A5039101231 @default.
• W4313454744 creator A5063904669 @default.
• W4313454744 date "2023-02-01" @default.
• W4313454744 modified "2023-10-17" @default.
• W4313454744 title "NLRP3 inflammasome in traumatic brain injury: Its implication in the disease pathophysiology and potential as a therapeutic target" @default.
• W4313454744 cites W1529674879 @default.
• W4313454744 cites W1535546167 @default.
• W4313454744 cites W1560867514 @default.
• W4313454744 cites W1561041814 @default.
• W4313454744 cites W1578695981 @default.
• W4313454744 cites W1703133408 @default.
• W4313454744 cites W1756750202 @default.
• W4313454744 cites W1859128422 @default.
• W4313454744 cites W1885912605 @default.
• W4313454744 cites W1966308623 @default.
• W4313454744 cites W1967524725 @default.
• W4313454744 cites W1973559709 @default.
• W4313454744 cites W1975110303 @default.
• W4313454744 cites W1980764967 @default.
• W4313454744 cites W1988610853 @default.
• W4313454744 cites W1992789370 @default.
• W4313454744 cites W1999881215 @default.
• W4313454744 cites W2003505305 @default.
• W4313454744 cites W2008225353 @default.
• W4313454744 cites W2012789061 @default.
• W4313454744 cites W2013700204 @default.
• W4313454744 cites W2015551349 @default.
• W4313454744 cites W2015918023 @default.
• W4313454744 cites W2016285277 @default.
• W4313454744 cites W2019260483 @default.
• W4313454744 cites W2023540371 @default.
• W4313454744 cites W2026209203 @default.
• W4313454744 cites W2029994068 @default.
• W4313454744 cites W2033323364 @default.
• W4313454744 cites W2035115523 @default.
• W4313454744 cites W2037600884 @default.
• W4313454744 cites W2043873577 @default.
• W4313454744 cites W2045262404 @default.
• W4313454744 cites W2049167261 @default.
• W4313454744 cites W2050259192 @default.
• W4313454744 cites W2051733986 @default.
• W4313454744 cites W2063858768 @default.
• W4313454744 cites W2064795783 @default.
• W4313454744 cites W2067448822 @default.
• W4313454744 cites W2067693365 @default.
• W4313454744 cites W2071766782 @default.
• W4313454744 cites W2072080234 @default.
• W4313454744 cites W2074059782 @default.
• W4313454744 cites W2079882002 @default.
• W4313454744 cites W2080644701 @default.
• W4313454744 cites W2081325915 @default.
• W4313454744 cites W2084158898 @default.
• W4313454744 cites W2086780154 @default.
• W4313454744 cites W2088164523 @default.
• W4313454744 cites W2091564585 @default.
• W4313454744 cites W2100953877 @default.
• W4313454744 cites W2101667799 @default.
• W4313454744 cites W2105605379 @default.
• W4313454744 cites W2107135681 @default.
• W4313454744 cites W2118403357 @default.
• W4313454744 cites W2119098586 @default.
• W4313454744 cites W2120815988 @default.
• W4313454744 cites W2128990399 @default.
• W4313454744 cites W2137368645 @default.
• W4313454744 cites W2140637559 @default.
• W4313454744 cites W2147569747 @default.
• W4313454744 cites W2150279416 @default.
• W4313454744 cites W2157551652 @default.
• W4313454744 cites W2163472422 @default.
• W4313454744 cites W2171704252 @default.
• W4313454744 cites W2274863439 @default.
• W4313454744 cites W2282875368 @default.
• W4313454744 cites W2288504555 @default.
• W4313454744 cites W2293374048 @default.
• W4313454744 cites W2312239103 @default.
• W4313454744 cites W2316762748 @default.
• W4313454744 cites W2317797070 @default.
• W4313454744 cites W2342062161 @default.
• W4313454744 cites W2442200025 @default.
• W4313454744 cites W2499852969 @default.
• W4313454744 cites W2526567150 @default.
• W4313454744 cites W2526775532 @default.
• W4313454744 cites W2541361002 @default.
• W4313454744 cites W2566478676 @default.
• W4313454744 cites W2568405449 @default.
• W4313454744 cites W2569649128 @default.
• W4313454744 cites W2573888969 @default.
• W4313454744 cites W2586825713 @default.
• W4313454744 cites W2587029358 @default.
• W4313454744 cites W2608155315 @default.
• W4313454744 cites W2614736523 @default.
• W4313454744 cites W2728496947 @default.
• W4313454744 cites W2734936313 @default.
• W4313454744 cites W2735385758 @default.
• W4313454744 cites W2735978036 @default.

• next