Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454752> ?p ?o ?g. }
- W4313454752 endingPage "122573" @default.
- W4313454752 startingPage "122573" @default.
- W4313454752 abstract "Polymeric nanoparticles are widely used drug delivery systems for cancer treatment due to their properties such as ease of passing through biological membranes, opportunity to modify drug release, specifically targeting drugs to diseased areas, and potential of reducing side effects. Here, we formulated irinotecan and Stattic co-loaded PLGA nanoparticles targeted to small cell lung cancer. Nanoparticles were successfully conjugated with CD56 antibody with a conjugation efficiency of 84.39 ± 1.01%, and characterization of formulated nanoparticles was conducted with in-vitro and in-vivo studies. Formulated particles had sizes in the range of 130-180 nm with PDI values smaller than 0.3. Encapsulation and active targeting of irinotecan and Stattic resulted in increased cytotoxicity and anti-cancer efficiency in-vitro. Furthermore, it was shown with ex-vivo biodistribution studies that conjugated nanoparticles were successfully targeted to CD56-expressing SCLC cells and distributed mainly to tumor tissue and lungs. Compliant with our hypothesis and literature, the STAT3 pathway was successfully inhibited with Stattic solution and Stattic loaded nanoparticles. Additionally, intravenous injection of conjugated co-loaded nanoparticles resulted in decreased side effects and better anti-tumor activity than individual solutions of drugs in SCLC tumor-bearing mice. These results may indicate a new treatment option for clinically aggressive small cell lung cancer." @default.
- W4313454752 created "2023-01-06" @default.
- W4313454752 creator A5006614463 @default.
- W4313454752 creator A5036241723 @default.
- W4313454752 creator A5041355015 @default.
- W4313454752 creator A5056354239 @default.
- W4313454752 creator A5061510247 @default.
- W4313454752 creator A5070157777 @default.
- W4313454752 date "2023-02-01" @default.
- W4313454752 modified "2023-10-18" @default.
- W4313454752 title "A novel combination for the treatment of small cell lung cancer: Active targeted irinotecan and stattic co-loaded PLGA nanoparticles" @default.
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