Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313454772> ?p ?o ?g. }
- W4313454772 abstract "Abstract Noninvasive prenatal diagnosis (NIPD) aims to detect fetal-related genetic disorders before birth by detecting markers in the peripheral blood of pregnant women, holding the potential in reducing the risk of fetal birth defects. Fetal-nucleated red blood cells (fNRBCs) can be used as biomarkers for NIPD, given their remarkable nature of carrying the entire genetic information of the fetus. Here, we review recent advances in NIPD technologies based on the isolation and analysis of fNRBCs. Conventional cell separation methods rely primarily on physical properties and surface antigens of fNRBCs, such as density gradient centrifugation, fluorescence-activated cell sorting, and magnetic-activated cell sorting. Due to the limitations of sensitivity and purity in Conventional methods, separation techniques based on micro-/nanomaterials have been developed as novel methods for isolating and enriching fNRBCs. We also discuss emerging methods based on microfluidic chips and nanostructured substrates for static and dynamic isolation of fNRBCs. Additionally, we introduce the identification techniques of fNRBCs and address the potential clinical diagnostic values of fNRBCs. Finally, we highlight the challenges and the future directions of fNRBCs as treatment guidelines in NIPD. Graphical Abstract" @default.
- W4313454772 created "2023-01-06" @default.
- W4313454772 creator A5000210131 @default.
- W4313454772 creator A5019623495 @default.
- W4313454772 creator A5027245585 @default.
- W4313454772 creator A5031835150 @default.
- W4313454772 creator A5033027302 @default.
- W4313454772 creator A5035361537 @default.
- W4313454772 creator A5045790986 @default.
- W4313454772 creator A5048613747 @default.
- W4313454772 creator A5060392201 @default.
- W4313454772 creator A5075198995 @default.
- W4313454772 date "2022-12-30" @default.
- W4313454772 modified "2023-10-05" @default.
- W4313454772 title "Noninvasive prenatal diagnosis targeting fetal nucleated red blood cells" @default.
- W4313454772 cites W1508623892 @default.
- W4313454772 cites W1541410667 @default.
- W4313454772 cites W1547367343 @default.
- W4313454772 cites W1643843356 @default.
- W4313454772 cites W172332421 @default.
- W4313454772 cites W1823116661 @default.
- W4313454772 cites W1858994110 @default.
- W4313454772 cites W1959077821 @default.
- W4313454772 cites W1963927755 @default.
- W4313454772 cites W1965879679 @default.
- W4313454772 cites W1968046362 @default.
- W4313454772 cites W1972867200 @default.
- W4313454772 cites W1974197921 @default.
- W4313454772 cites W1975320047 @default.
- W4313454772 cites W1975668690 @default.
- W4313454772 cites W1980442002 @default.
- W4313454772 cites W1981509058 @default.
- W4313454772 cites W1986430780 @default.
- W4313454772 cites W1986570408 @default.
- W4313454772 cites W1990734217 @default.
- W4313454772 cites W1991979236 @default.
- W4313454772 cites W1992796806 @default.
- W4313454772 cites W1994764480 @default.
- W4313454772 cites W1996576893 @default.
- W4313454772 cites W1996641286 @default.
- W4313454772 cites W2000905326 @default.
- W4313454772 cites W2001587206 @default.
- W4313454772 cites W2002589012 @default.
- W4313454772 cites W2004708117 @default.
- W4313454772 cites W2006390481 @default.
- W4313454772 cites W2007700456 @default.
- W4313454772 cites W2010162458 @default.
- W4313454772 cites W2010414559 @default.
- W4313454772 cites W2011295399 @default.
- W4313454772 cites W2014720310 @default.
- W4313454772 cites W2019033136 @default.
- W4313454772 cites W2019048697 @default.
- W4313454772 cites W2020619491 @default.
- W4313454772 cites W2022418588 @default.
- W4313454772 cites W2022425862 @default.
- W4313454772 cites W2022714591 @default.
- W4313454772 cites W2026729621 @default.
- W4313454772 cites W2031165496 @default.
- W4313454772 cites W2032658539 @default.
- W4313454772 cites W2033729501 @default.
- W4313454772 cites W2034615268 @default.
- W4313454772 cites W2035839455 @default.
- W4313454772 cites W2038454912 @default.
- W4313454772 cites W2042779590 @default.
- W4313454772 cites W2045150237 @default.
- W4313454772 cites W2045179868 @default.
- W4313454772 cites W2045338245 @default.
- W4313454772 cites W2048006749 @default.
- W4313454772 cites W2050811252 @default.
- W4313454772 cites W2054949346 @default.
- W4313454772 cites W2055437018 @default.
- W4313454772 cites W2057297160 @default.
- W4313454772 cites W2064274971 @default.
- W4313454772 cites W2064609638 @default.
- W4313454772 cites W2065196964 @default.
- W4313454772 cites W2066400670 @default.
- W4313454772 cites W2070436641 @default.
- W4313454772 cites W2075303273 @default.
- W4313454772 cites W2075324534 @default.
- W4313454772 cites W2075769784 @default.
- W4313454772 cites W2076390016 @default.
- W4313454772 cites W2077016335 @default.
- W4313454772 cites W2078512370 @default.
- W4313454772 cites W2078631070 @default.
- W4313454772 cites W2079673499 @default.
- W4313454772 cites W2079726850 @default.
- W4313454772 cites W2081954425 @default.
- W4313454772 cites W2082471725 @default.
- W4313454772 cites W2084316403 @default.
- W4313454772 cites W2085222547 @default.
- W4313454772 cites W2087062217 @default.
- W4313454772 cites W2090484374 @default.
- W4313454772 cites W2091514861 @default.
- W4313454772 cites W2091583677 @default.
- W4313454772 cites W2095398485 @default.
- W4313454772 cites W2095628434 @default.
- W4313454772 cites W2100786643 @default.
- W4313454772 cites W2100977485 @default.
- W4313454772 cites W2102150392 @default.
- W4313454772 cites W2102222126 @default.