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• W4313455259 abstract "Abstract Sensory‐independent Ca 2+ spiking regulates the development of mammalian sensory systems. In the immature cochlea, inner hair cells (IHCs) fire spontaneous Ca 2+ action potentials (APs) that are generated either intrinsically or by intercellular Ca 2+ waves in the nonsensory cells. The extent to which either or both of these Ca 2+ signalling mechansims are required for IHC maturation is unknown. We find that intrinsic Ca 2+ APs in IHCs, but not those elicited by Ca 2+ waves, regulate the maturation and maintenance of the stereociliary hair bundles. Using a mouse model in which the potassium channel Kir2.1 is reversibly overexpressed in IHCs ( Kir2.1‐ OE), we find that IHC membrane hyperpolarization prevents IHCs from generating intrinsic Ca 2+ APs but not APs induced by Ca 2+ waves. Absence of intrinsic Ca 2+ APs leads to the loss of mechanoelectrical transduction in IHCs prior to hearing onset due to progressive loss or fusion of stereocilia. RNA‐sequencing data show that pathways involved in morphogenesis, actin filament‐based processes, and Rho‐GTPase signaling are upregulated in Kir2.1‐ OE mice. By manipulating in vivo expression of Kir2.1 channels, we identify a “critical time period” during which intrinsic Ca 2+ APs in IHCs regulate hair‐bundle function." @default.
• W4313455259 created "2023-01-06" @default.
• W4313455259 creator A5012410991 @default.
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• W4313455259 date "2023-01-03" @default.
• W4313455259 modified "2023-10-18" @default.
• W4313455259 title "A critical period of prehearing spontaneous Ca²⁺ spiking is required for hair‐bundle maintenance in inner hair cells" @default.
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