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- W4313455884 abstract "The differentiation of B cells into antibody-secreting cells is fundamental for the generation of humoral immunity. In mammals, this process involves a series of metabolic and intracellular changes, not studied to date in teleost fish, where a clear distinction between naive B cells and plasmablasts/plasma cells (PCs) is still missing. Thus, in the current study, we have established that upon activation, teleost B cells undergo an expansion of the endoplasmic reticulum (ER) but experience no significant changes in mitochondria content. In parallel, the transcription of genes implicated in B cell differentiation increases, while that of mitochondrial genes decreases. In this context, ER monitoring has allowed us to distinguish between small cells with low amounts of ER (FSCloERlo B cells), that correspond to undifferentiated cells, and large cells with expanded ER (FSChiERhi B cells), characterized as plasmablasts. The results shed new light on the B cell differentiation process in teleosts and provide us with novel tools to study B cell function in these species." @default.
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- W4313455884 date "2023-01-01" @default.
- W4313455884 modified "2023-10-01" @default.
- W4313455884 title "Endoplasmic reticulum expansion throughout the differentiation of teleost B cells to plasmablasts" @default.
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- W4313455884 doi "https://doi.org/10.1016/j.isci.2022.105854" @default.
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