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- W4313457242 abstract "Abstract Acyl myricetins (monopropionyl-, dipropionyl-, and monooctanoyl-myricetin, termed as MP 1 , MP 2 , and MO 1 , respectively) were synthesized through enzymatic or non-enzymatic esterification reaction of myricetin aglycone. Structure study indicated the hydroxyl group at C4ʹ in B-ring was highly susceptible to acylation. Over its parental myricetin, acylated compounds showed enhanced lipophilicity (from 7.4- to 26.3-fold) and oxidative stability (from 1.9- to 3.1-fold) on the basis of log P and decay rate, respectively. MO 1 , presenting the physicochemical superiority compared to the others, provided lowest EC 50 value of 2.51 µM on inhibition of neutrotransmitter release and high CC 50 value of 58.96 µM, leading to widest therapeutic window. All myricetin esters did not show any irritation toxicity when assessed with a chicken embryo assay. This study describes information on acylation of myricetin that has not yet been explored, and suggests that MO 1 has anti-neuroexocytotic potential for industrial application due to its enhanced biological properties." @default.
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- W4313457242 date "2023-01-03" @default.
- W4313457242 modified "2023-10-18" @default.
- W4313457242 title "Synthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents" @default.
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- W4313457242 doi "https://doi.org/10.21203/rs.3.rs-2383780/v1" @default.
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