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- W4313457536 abstract "Abstract Background. Coronin 2A (CORO2A) is a member of the coronin family and reportedly functions as an oncogene in certain malignancies, although its correlation with prognosis and immune infiltration in different cancers remains unclear. Methods. Data were collected from the University of California Santa Cruz (UCSC), Human Protein Atlas (HPA), Tumor Immune Estimation Resource (TIMER), Tumor-Immune System Interactions (TISIDB) and Gene Set Enrichment Analysis (GSEA) databases. The differential expression of CORO2A, survival, clinical parameters, tumor mutational burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, DNA methyltransferases (DNMTs), tumor microenvironment (TME), immune-related genes (IRGs), immune infiltration, pathways and functions were analyzed using the R language software. Results. CORO2A was overexpressed in various malignancies, and correlated with clinical parameters, overall survival, disease-specific survival and progression-free survival in certain cancers. Furthermore, CORO2A was significantly correlated to the TMB, MSI, MMR genes, DNMTs, immune and stromal scores, IRGs and immune infiltration. GSEA further showed that CORO2A was associated with various immune-related pathways and functions in different cancer types. Conclusion. CORO2A is a promising prognostic and immunological marker for human cancers." @default.
- W4313457536 created "2023-01-06" @default.
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- W4313457536 date "2023-01-03" @default.
- W4313457536 modified "2023-09-30" @default.
- W4313457536 title "CORO2A is a pan-cancer prognostic biomarker and correlates with immune infiltration" @default.
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- W4313457536 doi "https://doi.org/10.21203/rs.3.rs-2192311/v1" @default.
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