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• W4313457595 abstract "Abstract Purpose The experiences of patients with diffuse large B-cell lymphoma (DLBCL) treated with Chimeric Antigen Receptor (CAR) T-cell therapy have received little attention. This study aimed to explore the treatment experience of patients with relapsed or refractory (R/R) B-cell lymphoma during CAR T-cell therapy in China. Methods This descriptive qualitative study was conducted using face-to-face semi-structured interviews with 21 DLBCL patients 0–2 years after CAR-T infusion. Two researchers independently coded the interviews in MAXQDA 2022, and the original data were analyzed by conventional content analysis. Results Four themes emerged from the transcripts: (1) physiological distress; (2) functional impacts; (3) psychological experience; and (4) support requirement. Participants expressed 29 short-term or long-term symptoms related to their disease and treatment that are influencing their daily life and function in a social setting. Participants expressed different negative emotions, polarized expectations about efficacy, and over-reliance on authoritative medical care. Their major concerns and hopes were achieving life goals, being treated with respect, obtaining more information about CAR T-cell therapy, and receiving government financial sponsorship. Conclusions Patients experienced short-term and long-term symptoms of physical distress. Patients who have experienced failure in CAR T-cell treatment also experienced strong negative emotions, such as dependency and guilt. They also required spiritual and financial information that are authentic. Our study may guide the development of standardized and comprehensive nursing care for R/R DLBCL patients undergoing CAR T-cell treatment in China." @default.
• W4313457595 created "2023-01-06" @default.
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• W4313457595 date "2023-01-03" @default.
• W4313457595 modified "2023-10-18" @default.
• W4313457595 title "Patients’ experience with Chimeric Antigen Receptor T-Cell Therapy for DLBCL in China: a qualitative study" @default.
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• W4313457595 doi "https://doi.org/10.21203/rs.3.rs-2399693/v1" @default.
• W4313457595 hasPublicationYear "2023" @default.
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