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- W4313458610 abstract "Abstract Light can effectively interrogate biological systems in a reversible and physiologically compatible manner with high spatiotemporal precision. Understanding the biophysics of photo-induced processes in bio-systems is crucial for achieving relevant clinical applications. Employing membranes doped with the photolipid azobenzene-phosphatidylcholine (azo-PC), we provide a holistic picture of light-triggered changes in membrane kinetics, morphology and material properties obtained from correlative studies on cell-sized vesicles, Langmuir monolayers, supported lipid bilayers and molecular dynamics simulations. Light-induced membrane area increase as high as ∼25% and a 10-fold decrease in the membrane bending rigidity is observed upon trans -to- cis azo-PC isomerization associated with membrane leaflet coupling and molecular curvature changes. Vesicle electrodeformation measurements and atomic force microscopy reveal that trans azo-PC bilayers are thicker than POPC bilayer but have higher specific membrane capacitance and dielectric constant suggesting an increased ability to store electric charges across the membrane. Lastly, incubating POPC vesicles with azo-PC solutions resulted in the insertion of azo-PC in the membrane enabling them to become photoresponsive. All these results demonstrate that light can be used to finely manipulate the shape, mechanical and electric properties of photolipid-doped minimal cell models and liposomal drug carriers, thus, presenting a promising therapeutic alternative for the repair of cellular disorders." @default.
- W4313458610 created "2023-01-06" @default.
- W4313458610 creator A5004883364 @default.
- W4313458610 creator A5010228314 @default.
- W4313458610 creator A5048026386 @default.
- W4313458610 creator A5066141875 @default.
- W4313458610 creator A5071086704 @default.
- W4313458610 creator A5071556687 @default.
- W4313458610 date "2023-01-03" @default.
- W4313458610 modified "2023-10-18" @default.
- W4313458610 title "Photomanipulation of minimal synthetic cells: area increase, softening and interleaflet coupling of membrane models doped with azobenzene-lipid photoswitches" @default.
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