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- W4313459048 abstract "Abstract In an attempt to search for new natural product-based antitumor agents, a series of novel thiazolidinone derivatives of dehydroabietic acid-based B ring-fused-thiazole were designed and synthesized. The primary antitumor tests showed that compounds 5m exhibited almost the best inhibitory activity against the tested cancer cells. The computational study suggested NOTCH1, IGF1R, TLR4, and KDR were the core targets of the title compounds, and the IC 50 of SCC9 and Cal27 is strong correlation with the binding ability of TLR4 and compounds." @default.
- W4313459048 created "2023-01-06" @default.
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- W4313459048 date "2023-01-03" @default.
- W4313459048 modified "2023-10-18" @default.
- W4313459048 title "Synthesis, antitumor evaluation and computational study of thiazolidinone derivatives of dehydroabietic acid-based B ring-fused-thiazole" @default.
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- W4313459048 doi "https://doi.org/10.21203/rs.3.rs-2405215/v1" @default.
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