FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313461021> ?p ?o ?g. }

• W4313461021 endingPage "e0279578" @default.
• W4313461021 startingPage "e0279578" @default.
• W4313461021 abstract "The SARS-CoV-2 virus is currently causing a global pandemic. Infection may result in a systemic disease called COVID-19, affecting primarily the respiratory tract. Often the gastrointestinal tract and kidneys also become involved. Angiotensin converting enzyme 2 (ACE2) serves as the receptor for SARS-CoV-2. The membrane proteins, Transmembrane serine protease 2 (TMPRSS2) and Neuropilin 1 (NRP1) are accessory proteins facilitating the virus entry. In this study we show that the human proximal kidney tubules, express these factors. We hypothesized that cancers derived from proximal tubules as clear cell (CCRCC) and papillary renal cell carcinoma (PRCC), retain the expression of the SARS-CoV-2 entry factors making these cancers susceptible to SARS-CoV-2 infection. We used bioinformatics, western blotting, and assessment of tissue micro arrays (TMA) including 263 cases of CCRCC, 139 cases of PRCC and 18 cases of chromophobe RCC to demonstrate that the majority of CCRCC and PRCC cases retained the RNA and protein expression of the entry factors for SARS-CoV-2. We furthermore show that SARS-CoV-2 virus propagated robustly in primary cultures of CCRCC and PRCC cells with a visible virus cytopathogenic effect correlating with viral RNA expression levels. We also noted that the delta-variant of SARS-CoV-2 causes cancer cells to form syncytia in-vitro. This phenomenon was also identified histologically in CCRCC tissue from a patient that had been hospitalized for COVID-19, twelve months prior to nephrectomy. Our data provide insights into SARS-CoV-2 infectivity in renal cell carcinoma and that the virus causes a distinct cytopathogenic effect." @default.
• W4313461021 created "2023-01-06" @default.
• W4313461021 creator A5002092936 @default.
• W4313461021 creator A5006951133 @default.
• W4313461021 creator A5013065781 @default.
• W4313461021 creator A5022920523 @default.
• W4313461021 creator A5030795201 @default.
• W4313461021 creator A5044630009 @default.
• W4313461021 creator A5059258485 @default.
• W4313461021 creator A5062849817 @default.
• W4313461021 creator A5068261461 @default.
• W4313461021 creator A5070275752 @default.
• W4313461021 creator A5077167332 @default.
• W4313461021 creator A5078801352 @default.
• W4313461021 date "2023-01-03" @default.
• W4313461021 modified "2023-10-03" @default.
• W4313461021 title "SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma" @default.
• W4313461021 cites W2038169801 @default.
• W4313461021 cites W2114104545 @default.
• W4313461021 cites W2145825942 @default.
• W4313461021 cites W2154497662 @default.
• W4313461021 cites W2230320310 @default.
• W4313461021 cites W2742449822 @default.
• W4313461021 cites W2754660884 @default.
• W4313461021 cites W2948662515 @default.
• W4313461021 cites W3009912996 @default.
• W4313461021 cites W3011483298 @default.
• W4313461021 cites W3014703367 @default.
• W4313461021 cites W3024126428 @default.
• W4313461021 cites W3026924203 @default.
• W4313461021 cites W3040801404 @default.
• W4313461021 cites W3041374933 @default.
• W4313461021 cites W3094419073 @default.
• W4313461021 cites W3157117268 @default.
• W4313461021 cites W4247265560 @default.
• W4313461021 doi "https://doi.org/10.1371/journal.pone.0279578" @default.
• W4313461021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36595529" @default.
• W4313461021 hasPublicationYear "2023" @default.
• W4313461021 type Work @default.
• W4313461021 citedByCount "4" @default.
• W4313461021 countsByYear W43134610212023 @default.
• W4313461021 crossrefType "journal-article" @default.
• W4313461021 hasAuthorship W4313461021A5002092936 @default.
• W4313461021 hasAuthorship W4313461021A5006951133 @default.
• W4313461021 hasAuthorship W4313461021A5013065781 @default.
• W4313461021 hasAuthorship W4313461021A5022920523 @default.
• W4313461021 hasAuthorship W4313461021A5030795201 @default.
• W4313461021 hasAuthorship W4313461021A5044630009 @default.
• W4313461021 hasAuthorship W4313461021A5059258485 @default.
• W4313461021 hasAuthorship W4313461021A5062849817 @default.
• W4313461021 hasAuthorship W4313461021A5068261461 @default.
• W4313461021 hasAuthorship W4313461021A5070275752 @default.
• W4313461021 hasAuthorship W4313461021A5077167332 @default.
• W4313461021 hasAuthorship W4313461021A5078801352 @default.
• W4313461021 hasBestOaLocation W43134610211 @default.
• W4313461021 hasConcept C140704245 @default.
• W4313461021 hasConcept C142724271 @default.
• W4313461021 hasConcept C159047783 @default.
• W4313461021 hasConcept C2522874641 @default.
• W4313461021 hasConcept C2777472916 @default.
• W4313461021 hasConcept C2778560582 @default.
• W4313461021 hasConcept C2781278892 @default.
• W4313461021 hasConcept C502942594 @default.
• W4313461021 hasConcept C58475186 @default.
• W4313461021 hasConcept C71924100 @default.
• W4313461021 hasConcept C78795084 @default.
• W4313461021 hasConcept C82210918 @default.
• W4313461021 hasConcept C86803240 @default.
• W4313461021 hasConceptScore W4313461021C140704245 @default.
• W4313461021 hasConceptScore W4313461021C142724271 @default.
• W4313461021 hasConceptScore W4313461021C159047783 @default.
• W4313461021 hasConceptScore W4313461021C2522874641 @default.
• W4313461021 hasConceptScore W4313461021C2777472916 @default.
• W4313461021 hasConceptScore W4313461021C2778560582 @default.
• W4313461021 hasConceptScore W4313461021C2781278892 @default.
• W4313461021 hasConceptScore W4313461021C502942594 @default.
• W4313461021 hasConceptScore W4313461021C58475186 @default.
• W4313461021 hasConceptScore W4313461021C71924100 @default.
• W4313461021 hasConceptScore W4313461021C78795084 @default.
• W4313461021 hasConceptScore W4313461021C82210918 @default.
• W4313461021 hasConceptScore W4313461021C86803240 @default.
• W4313461021 hasFunder F4320321491 @default.
• W4313461021 hasFunder F4320324839 @default.
• W4313461021 hasFunder F4320334078 @default.
• W4313461021 hasIssue "1" @default.
• W4313461021 hasLocation W43134610211 @default.
• W4313461021 hasLocation W43134610212 @default.
• W4313461021 hasLocation W43134610213 @default.
• W4313461021 hasOpenAccess W4313461021 @default.
• W4313461021 hasPrimaryLocation W43134610211 @default.
• W4313461021 hasRelatedWork W1951049417 @default.
• W4313461021 hasRelatedWork W1973432828 @default.
• W4313461021 hasRelatedWork W2034555737 @default.
• W4313461021 hasRelatedWork W2054667493 @default.
• W4313461021 hasRelatedWork W2563822867 @default.
• W4313461021 hasRelatedWork W2909218662 @default.
• W4313461021 hasRelatedWork W3210563257 @default.
• W4313461021 hasRelatedWork W4283802257 @default.

• next