FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313461943> ?p ?o ?g. }

• W4313461943 abstract "Abstract Purpose Most differentiated thyroid cancer (DTC) patients have a good prognosis after surgery, but radioiodine refractory differentiated thyroid cancer (RAIR-DTC) patients have a significantly reduced five-year survival rate (< 60%) and a significantly increased recurrence rate (> 30%). This study aimed to clarify the tescalcin (TESC) role in promoting the malignant PTC progression and providing a potential target for RAIR-DTC treatment. Methods We analyzed TESC expression and clinicopathological characteristics using the Cancer Genome Atlas (TCGA) and performed qRT-PCR on tissue samples. TPC-1 and IHH4 proliferation, migration, and invasion were detected after transfection with TESC-RNAi. Using Western blot (WB), several EMT-related indicators were detected. Moreover, iodine uptake of TPC-1 and IHH4 after transfection with TESC-RNAi was detected. Finally, NIS, ERK1/2, and p-ERK1/2 levels were determined by WB. Results TESC was significantly upregulated in DTC tissues and positively correlated with BRAF V600E mutation based on data analysis from TCGA and our center. Reduced expression of TESC in both IHH-4 (BRAF V600E mutation) and TPC-1 (BRAF V600E wild type) cells significantly inhibited cell proliferation, migration, and invasion. It downregulated the EMT pathway markers Vimentin and N-cadherin, and increased E- cadherin. Moreover, TESC knockdown significantly inhibited ERK1/2 phosphorylation and decreased NIS expression in DTC cells, with a remarkably increased iodine uptake rate. Conclusions TESC was highly expressed in DTC tissues and may have promoted metastasis through EMT and induced iodine resistance by downregulating NIS in DTC cells." @default.
• W4313461943 created "2023-01-06" @default.
• W4313461943 creator A5002925255 @default.
• W4313461943 creator A5005066823 @default.
• W4313461943 creator A5006066186 @default.
• W4313461943 creator A5007661222 @default.
• W4313461943 creator A5015169879 @default.
• W4313461943 creator A5020473510 @default.
• W4313461943 creator A5021110763 @default.
• W4313461943 creator A5024792241 @default.
• W4313461943 creator A5032358575 @default.
• W4313461943 creator A5075705058 @default.
• W4313461943 creator A5077897513 @default.
• W4313461943 creator A5079166554 @default.
• W4313461943 creator A5079368655 @default.
• W4313461943 date "2023-01-03" @default.
• W4313461943 modified "2023-10-18" @default.
• W4313461943 title "Mechanism of TESC in the regulation of iodine resistance in differentiated thyroid carcinoma based on ERK-NIS axis" @default.
• W4313461943 cites W1538981488 @default.
• W4313461943 cites W1574154648 @default.
• W4313461943 cites W1985333426 @default.
• W4313461943 cites W2009364090 @default.
• W4313461943 cites W2065271250 @default.
• W4313461943 cites W2082832566 @default.
• W4313461943 cites W2083270525 @default.
• W4313461943 cites W2101888941 @default.
• W4313461943 cites W2107278092 @default.
• W4313461943 cites W2116542352 @default.
• W4313461943 cites W2116602172 @default.
• W4313461943 cites W2120775347 @default.
• W4313461943 cites W2139273584 @default.
• W4313461943 cites W2346451077 @default.
• W4313461943 cites W2849244694 @default.
• W4313461943 cites W2904679600 @default.
• W4313461943 cites W2965295034 @default.
• W4313461943 cites W2979995829 @default.
• W4313461943 cites W3040158249 @default.
• W4313461943 cites W3159027907 @default.
• W4313461943 cites W4200167807 @default.
• W4313461943 cites W4206841660 @default.
• W4313461943 cites W4213178952 @default.
• W4313461943 cites W4281645867 @default.
• W4313461943 cites W4283069990 @default.
• W4313461943 doi "https://doi.org/10.21203/rs.3.rs-2390860/v1" @default.
• W4313461943 hasPublicationYear "2023" @default.
• W4313461943 type Work @default.
• W4313461943 citedByCount "0" @default.
• W4313461943 crossrefType "posted-content" @default.
• W4313461943 hasAuthorship W4313461943A5002925255 @default.
• W4313461943 hasAuthorship W4313461943A5005066823 @default.
• W4313461943 hasAuthorship W4313461943A5006066186 @default.
• W4313461943 hasAuthorship W4313461943A5007661222 @default.
• W4313461943 hasAuthorship W4313461943A5015169879 @default.
• W4313461943 hasAuthorship W4313461943A5020473510 @default.
• W4313461943 hasAuthorship W4313461943A5021110763 @default.
• W4313461943 hasAuthorship W4313461943A5024792241 @default.
• W4313461943 hasAuthorship W4313461943A5032358575 @default.
• W4313461943 hasAuthorship W4313461943A5075705058 @default.
• W4313461943 hasAuthorship W4313461943A5077897513 @default.
• W4313461943 hasAuthorship W4313461943A5079166554 @default.
• W4313461943 hasAuthorship W4313461943A5079368655 @default.
• W4313461943 hasBestOaLocation W43134619431 @default.
• W4313461943 hasConcept C104317684 @default.
• W4313461943 hasConcept C11960822 @default.
• W4313461943 hasConcept C126322002 @default.
• W4313461943 hasConcept C127561419 @default.
• W4313461943 hasConcept C134018914 @default.
• W4313461943 hasConcept C147447768 @default.
• W4313461943 hasConcept C173396325 @default.
• W4313461943 hasConcept C178790620 @default.
• W4313461943 hasConcept C185592680 @default.
• W4313461943 hasConcept C204232928 @default.
• W4313461943 hasConcept C2779761222 @default.
• W4313461943 hasConcept C2993294228 @default.
• W4313461943 hasConcept C502942594 @default.
• W4313461943 hasConcept C526584372 @default.
• W4313461943 hasConcept C539932907 @default.
• W4313461943 hasConcept C54009773 @default.
• W4313461943 hasConcept C54355233 @default.
• W4313461943 hasConcept C55493867 @default.
• W4313461943 hasConcept C57074206 @default.
• W4313461943 hasConcept C71924100 @default.
• W4313461943 hasConcept C81885089 @default.
• W4313461943 hasConcept C86803240 @default.
• W4313461943 hasConceptScore W4313461943C104317684 @default.
• W4313461943 hasConceptScore W4313461943C11960822 @default.
• W4313461943 hasConceptScore W4313461943C126322002 @default.
• W4313461943 hasConceptScore W4313461943C127561419 @default.
• W4313461943 hasConceptScore W4313461943C134018914 @default.
• W4313461943 hasConceptScore W4313461943C147447768 @default.
• W4313461943 hasConceptScore W4313461943C173396325 @default.
• W4313461943 hasConceptScore W4313461943C178790620 @default.
• W4313461943 hasConceptScore W4313461943C185592680 @default.
• W4313461943 hasConceptScore W4313461943C204232928 @default.
• W4313461943 hasConceptScore W4313461943C2779761222 @default.
• W4313461943 hasConceptScore W4313461943C2993294228 @default.
• W4313461943 hasConceptScore W4313461943C502942594 @default.
• W4313461943 hasConceptScore W4313461943C526584372 @default.
• W4313461943 hasConceptScore W4313461943C539932907 @default.
• W4313461943 hasConceptScore W4313461943C54009773 @default.

• next