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- W4313462570 abstract "The performance of a number of pharmaceutical products depends upon the dispersion of powders and the adhesion of powder to either package materials or to delivery devices. Other work previously presented by the current authors has discussed the implications for adhesion between relevant materials based upon various surface thermodynamic models of adhesion. Such work indicates that variable surface contamination is, in significant part, responsible for the observed product variation in dry powder inhalation products. Little attention, however, has been given to the direct measurement of adhesion between relevant components. In this work, the application of scanning probe microscopy (SPM) and the colloidal probe method to the study of adhesion between pharmaceutical powders and other relevant surfaces is discussed as are the implications for the use of surface engineering to achieve enhanced product performance. More specifically, particle-particle and particle-capsule adhesion is discussed. Average adhesion forces for contacts between the selected materials were determined. The measured average adhesion forces are consistent with particles interacting primarily through Lifshitz-van der Waals interactions. It appears that these average adhesion forces can be used to understand the relative importance of the adhesion between given components." @default.
- W4313462570 created "2023-01-06" @default.
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- W4313462570 date "2023-01-03" @default.
- W4313462570 modified "2023-09-27" @default.
- W4313462570 title "Direct adhesion measurements between pharmaceutical materials" @default.
- W4313462570 doi "https://doi.org/10.1201/9780429070716-16" @default.
- W4313462570 hasPublicationYear "2023" @default.
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