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- W4313462669 abstract "Arterial thrombi consist mainly of platelets and fibrin polymer, which is the biopolymer produced in the final step of the coagulation cascade. The objective of this study was to investigate the role of the fibrin polymer network in the resistance of a clot to fragmentation under shear flow. To this end, a fibrin clot model consisting of monodispersed latex particles coated with fibrin polymer adhering to a glass plate which is also coated with fibrin polymer is considered as a representative model of native clots. A shear flow chamber was especially designed to determine the adhesion force due to specific fibrin/fibrin interactions by measuring the wall shear stress required to remove the particles from the plate. A complete series of experiments has been performed to investigate three different physiological cases associated with three different surface coated conditions: a fibrin monolayer, a fibrin bilayer and a fibrin bilayer degraded by a physiological fibrinolytic protein. A balance of forces and torque on particles, taking into account the elastic behavior of fibrin/fibrin bonds, is used to interpret the results in terms of a net adhesion force due to fibrin/fibrin polymers interactions. It is shown that the adhesion is higher when the surface is coated by a fibrin bilayer. Furthermore, the adhesion diminishes significantly when the fibrin bilayer coating the surface is degraded." @default.
- W4313462669 created "2023-01-06" @default.
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- W4313462669 date "2023-01-03" @default.
- W4313462669 modified "2023-10-16" @default.
- W4313462669 title "Removal of fibrin coated particles from surfaces" @default.
- W4313462669 doi "https://doi.org/10.1201/9780429070716-26" @default.
- W4313462669 hasPublicationYear "2023" @default.
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