Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313462831> ?p ?o ?g. }
- W4313462831 abstract "ABSTRACT Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and proinflammatory activity. Although this response must be sufficiently vigorous to ensure the successful clearance of pathogens, it must also be carefully regulated to prevent tissue damage. This is controlled in part by CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2), a transcriptional coregulator that limits ISG expression by inhibiting STAT1 and IRF1. Here, we show that the closely related Cited1 is an ISG, which is expressed in a STAT1-dependent manner, and that IFNγ stimulates the nuclear accumulation of CITED1 protein. In contrast to CITED2, ectopic CITED1 enhanced the expression of a subset of ISGs, including Ccl2, Ifit3b, Isg15 and Oas2. This effect was reversed in a Cited1-null cell line produced by CRISPR-based genomic editing. Collectively, these data show that CITED1 maintains proinflammatory gene expression during periods of prolonged IFNγ exposure and suggest that there is an antagonistic relationship between CITED proteins in the regulation of macrophage inflammatory function. This article has an associated First Person interview with the first author of the paper." @default.
- W4313462831 created "2023-01-06" @default.
- W4313462831 creator A5001748102 @default.
- W4313462831 creator A5006384073 @default.
- W4313462831 creator A5012930183 @default.
- W4313462831 creator A5018601597 @default.
- W4313462831 creator A5041305921 @default.
- W4313462831 creator A5058799184 @default.
- W4313462831 creator A5061231829 @default.
- W4313462831 creator A5069834801 @default.
- W4313462831 creator A5072706405 @default.
- W4313462831 date "2022-01-03" @default.
- W4313462831 modified "2023-09-26" @default.
- W4313462831 title "Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1" @default.
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