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• W4313462836 abstract "Abstract Background: There are many studies regarding the increased relationship between pregnancy outcomes and obstetrical complications of singleton with endometriosis such as preterm birth, preeclampsia, placenta previa, and small for gestational age. However, there was limited evidence of twin pregnancies with endometriosis. The objective of this study was to compare the pregnancy outcomes and obstetrical complications in twin pregnancies with endometriosis or without endometriosis in single institution. Methods: Between January 2011 and July 2022, a cohort of twin pregnancies delivered at single institution was retrospectively analyzed. Patients who underwent surgical treatment before pregnancy and had histological confirmation; had visual or histological confirmation during cesarean section; and those with antenatal ultrasonographic findings of typical ovarian endometriosis and underwent vaginal delivery were included in the endometriosis group. Pregnancy outcomes and obstetrical complications were compared between the two groups. Results: A total of 1,951 patients were examined, of whom 143 (7.3%) were included in the endometriosis group. Maternal body mass index (BMI) was significantly lower in the endometriosis group (p<0.001). However, there were no significant differences in maternal age, mode of conception, and chorionicity. There were also no significant differences in pregnancy outcomes: gestational age at delivery (p=0.619), rate of delivery before 37weeks (p=0.728), and mode of delivery (p=0.698). However, some obstetrical complications showed significantly higher rates in the endometriosis group: placenta previa (p=0.038), small for gestational age <10% (p=0.039), and postpartum hemorrhage (p=0.006). Logistic regression analyses performed after adjusted for BMI showed that patient with endometriosis had a higher risk of developing placenta previa (odds ratios (OR) 2.191; 95% confidence intervals (CI) 1.051-4.568), and postpartum hemorrhage (OR, 2.506; 95% CI, 1.444-4.348). After multivariable analyses, postpartum hemorrhage was significantly higher in patients with endometriosis (OR, 2.264; 95% CI, 1.265-4.054). Conclusions: Twin pregnancies with endometriosis had a significantly higher risk of postpartum hemorrhage. To confirm these outcomes, further large prospective studies are required. Trial registration : retrospectively registered" @default.
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• W4313462836 date "2023-01-03" @default.
• W4313462836 modified "2023-10-17" @default.
• W4313462836 title "Pregnancy outcomes and obstetrical complications of twin pregnancies with endometriosis: A single center cohort study" @default.
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• W4313462836 doi "https://doi.org/10.21203/rs.3.rs-2376445/v1" @default.
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