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- W4313462956 abstract "Sarcopenia is a syndrome of age-related loss of muscle mass and strength that seriously affects human health, and there are currently no effective drugs to treat the disease. Linolenic acid as a common n-3 polyunsaturated fatty acid (n-3 PUFA) is known to have many beneficial functions. Some studies have found that n-3 PUFA might have the potential to improve sarcopenia. In this study, Caenorhabditis elegans (C. elegans) was used as a model animal to investigate the effects of linolenic acid on C. elegans muscles. The results showed that 50 μg mL-1 linolenic acid significantly improved sarcopenia by repairing mitochondrial function by promoting mitophagy and fighting oxidative stress (p < 0.05). This included the increase of the expression of the mitophagy gene pink-1 and DAF-16/FOXO transcription factors, respectively, by linolenic acid. This study could provide some evidence for the application of n-3 PUFA in improving sarcopenia." @default.
- W4313462956 created "2023-01-06" @default.
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- W4313462956 date "2023-01-01" @default.
- W4313462956 modified "2023-10-17" @default.
- W4313462956 title "Linolenic acid ameliorates sarcopenia in <i>C. elegans</i> by promoting mitophagy and fighting oxidative stress" @default.
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- W4313462956 doi "https://doi.org/10.1039/d2fo02974j" @default.
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