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• W4313463016 abstract "Abstract Background Lactulose has been considered to be an effective prebiotic protect intestinal mucosal injury in pigs. Bacillus coagulans ( B. coagulans ) is known as ‘the king of probiotics’ due to its high stability in the gastrointestinal tract, non-toxic effects, as well as high pharmacological activity. Our previous in vitro study indicating that the combination of lactulose and B. coagulans may be a good candidate as alternative of antibiotic growth promoters. However, the in vivo effects of lactulose and B. coagulans on growth and intestinal health under immune challenge in piglets remains unclear. The objective of this study is to explore the possibility of symbiotic containing lactulose and B. coagulans as alternative of antibiotic growth promoter in piglets and its effects on the intestinal mucosal injury and barrier dysfunction under immune challenge. Methods A total of 24 weaned male piglets were randomly assigned to 4 groups: CTR -saline , LPS -LPS , ANT -LPS and SYN -LPS groups, respectively. Piglets in the CTR -saline and LPS -LPS group were fed basal diet, while other piglets were fed either with 75 mg/kg chlortetracycline (CTC) or synbiotic mixture of 10 g/kg lactulose and 2×10 9 CFU/kg B. coagulans for 32 days before intraperitoneal injection of saline or lipopolysaccharide (LPS) (100 µg/kg BW), respectively. Piglets were sacrificed 4 h after LPS injection to collect samples for determining intestinal morphology, integrity and barrier functions as well as relative genes and protein expression analysis. Results Our data shown that dietary supplementation of synbiotic mixture of lactulose and B. coagulans had higher feed efficiency than CTC and CON. Under acute immune stress, LPS injection induced higher serum diamine oxidase activities, D -lactic acid levels, and endotoxin status, lower villus height and ratio of villus height to crypt depth, greater mRNA and lower protein expression related tight junction in both jejunum and ileum. Moreover, higher apoptosis index and higher protein expression of Bax and caspase-3 were also observed in LPS challenge group. Surprisingly, dietary synbiotic mixture with lactulose and B. coagulans remarkably protected against LPS-induced intestinal damage, barrier dysfunction and higher apoptosis progress as well as CTC. Conclusions Our in vivo data suggest that dietary supplementation of synbiotic mixture with lactulose and B. coagulans resulted in higher feed efficiency, and show greater resilience to LPS-induced intestinal morphology damage, barrier dysfunction and aggressive apoptosis in piglets as well as the protective effects of CTC. Those results indicating that synbiotic mixture of lactulose and B. coagulans as novel synbiotic shown beneficial effects on the performance and resilience to acute immune stress in piglets." @default.
• W4313463016 created "2023-01-06" @default.
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• W4313463016 date "2023-01-03" @default.
• W4313463016 modified "2023-09-23" @default.
• W4313463016 title "The synbiotic mixture of lactulose and Bacillus coagulans protect intestinal barrier dysfunction and apoptosis in weaned piglets challenged with lipopolysaccharide" @default.
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• W4313463016 doi "https://doi.org/10.21203/rs.3.rs-2392565/v1" @default.
• W4313463016 hasPublicationYear "2023" @default.
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