Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313463224> ?p ?o ?g. }
- W4313463224 endingPage "154337" @default.
- W4313463224 startingPage "154337" @default.
- W4313463224 abstract "Antibiotic resistance is a huge public health security crisis around the world. Darobactin is a ribosomally produced and post-translationally modified heptapeptide antibiotic with a unique bicyclic structure. This compound is highly effective against a variety of Gram-negative pathogens by targeting the outer membrane protein BamA. The biosynthetic pathway of darobactin involves a highly versatile radical S-adenosylmethionine (SAM) enzyme DarE, which is responsible for the formation of the unique indole-based bicyclic cyclophane structure. Recently, total synthesis of darobactin was achieved independently by different research groups, utilizing Larock heteroannulation as a key step to construct the bicyclic structure. This paper reviews the recent studies in the chemistry and biology of darobactin, including biosynthetic pathway, chemical synthesis, antibacterial mode of action, and bioengineering studies." @default.
- W4313463224 created "2023-01-06" @default.
- W4313463224 creator A5002500795 @default.
- W4313463224 creator A5003715923 @default.
- W4313463224 creator A5049791270 @default.
- W4313463224 date "2023-02-01" @default.
- W4313463224 modified "2023-10-18" @default.
- W4313463224 title "Chemical synthesis and biosynthesis of darobactin" @default.
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