Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313467575> ?p ?o ?g. }
- W4313467575 endingPage "66" @default.
- W4313467575 startingPage "66" @default.
- W4313467575 abstract "The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing-promoting capacities along with superior homing ability. The ABCB5+ MSCs can be easily accessed from discarded skin samples, expanded, and delivered as a highly homogenous medicinal product with standardized potency. A range of preclinical studies has suggested therapeutic efficacy of ABCB5+ MSCs in a variety of currently uncurable skin and non-skin inflammatory diseases, which has been substantiated thus far by distinct clinical trials in chronic skin wounds or recessive dystrophic epidermolysis bullosa. Therefore, skin-derived ABCB5+ MSCs have the potential to provide a breakthrough at the forefront of MSC-based therapies striving to fulfill current unmet medical needs. The most recent milestones in this regard are the approval of a phase III pivotal trial of ABCB5+ MSCs for treatment of recessive dystrophic and junctional epidermolysis bullosa by the US Food and Drug Administration, and national market access of ABCB5+ MSCs (AMESANAR®) for therapy-refractory chronic venous ulcers under the national hospital exemption pathway in Germany." @default.
- W4313467575 created "2023-01-06" @default.
- W4313467575 creator A5008099067 @default.
- W4313467575 creator A5022291678 @default.
- W4313467575 creator A5031962714 @default.
- W4313467575 creator A5054721822 @default.
- W4313467575 creator A5089843842 @default.
- W4313467575 date "2022-12-21" @default.
- W4313467575 modified "2023-10-14" @default.
- W4313467575 title "Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine" @default.
- W4313467575 cites W101324336 @default.
- W4313467575 cites W1523617147 @default.
- W4313467575 cites W1594860261 @default.
- W4313467575 cites W1723013642 @default.
- W4313467575 cites W1969795656 @default.
- W4313467575 cites W1974603116 @default.
- W4313467575 cites W1979094948 @default.
- W4313467575 cites W1990757263 @default.
- W4313467575 cites W1994594051 @default.
- W4313467575 cites W1995102699 @default.
- W4313467575 cites W1995212212 @default.
- W4313467575 cites W2002282481 @default.
- W4313467575 cites W2006628284 @default.
- W4313467575 cites W2013970253 @default.
- W4313467575 cites W2017712207 @default.
- W4313467575 cites W2018258390 @default.
- W4313467575 cites W2019583561 @default.
- W4313467575 cites W2020466593 @default.
- W4313467575 cites W2023301282 @default.
- W4313467575 cites W2024623214 @default.
- W4313467575 cites W2025371271 @default.
- W4313467575 cites W2028901814 @default.
- W4313467575 cites W2036263091 @default.
- W4313467575 cites W2036452348 @default.
- W4313467575 cites W2038399651 @default.
- W4313467575 cites W2038815061 @default.
- W4313467575 cites W2038908080 @default.
- W4313467575 cites W2042844369 @default.
- W4313467575 cites W2047010928 @default.
- W4313467575 cites W2049683781 @default.
- W4313467575 cites W2049731799 @default.
- W4313467575 cites W2053366731 @default.
- W4313467575 cites W2053545712 @default.
- W4313467575 cites W2055573584 @default.
- W4313467575 cites W2056064788 @default.
- W4313467575 cites W2056552961 @default.
- W4313467575 cites W2058071683 @default.
- W4313467575 cites W2065565273 @default.
- W4313467575 cites W2068345616 @default.
- W4313467575 cites W2070525877 @default.
- W4313467575 cites W2075123157 @default.
- W4313467575 cites W2087353148 @default.
- W4313467575 cites W2089440777 @default.
- W4313467575 cites W2091169302 @default.
- W4313467575 cites W2091714475 @default.
- W4313467575 cites W2091784214 @default.
- W4313467575 cites W2098379861 @default.
- W4313467575 cites W2098706786 @default.
- W4313467575 cites W2103489164 @default.
- W4313467575 cites W2103883318 @default.
- W4313467575 cites W2107919309 @default.
- W4313467575 cites W2113358240 @default.
- W4313467575 cites W2114484863 @default.
- W4313467575 cites W2116553639 @default.
- W4313467575 cites W2120803742 @default.
- W4313467575 cites W2122412604 @default.
- W4313467575 cites W2129834060 @default.
- W4313467575 cites W2130362099 @default.
- W4313467575 cites W2131876608 @default.
- W4313467575 cites W2132075120 @default.
- W4313467575 cites W2133938655 @default.
- W4313467575 cites W2134427060 @default.
- W4313467575 cites W2136356167 @default.
- W4313467575 cites W2144268541 @default.
- W4313467575 cites W2152773911 @default.
- W4313467575 cites W2153949260 @default.
- W4313467575 cites W2159999899 @default.
- W4313467575 cites W2162412444 @default.
- W4313467575 cites W2163809998 @default.
- W4313467575 cites W2164481653 @default.
- W4313467575 cites W2165319206 @default.
- W4313467575 cites W2169465258 @default.
- W4313467575 cites W2170525767 @default.
- W4313467575 cites W2172680325 @default.
- W4313467575 cites W2182766838 @default.
- W4313467575 cites W2227687771 @default.
- W4313467575 cites W2286803093 @default.
- W4313467575 cites W2299081204 @default.
- W4313467575 cites W2299727915 @default.
- W4313467575 cites W2316570837 @default.
- W4313467575 cites W2323330456 @default.
- W4313467575 cites W2330187145 @default.
- W4313467575 cites W2335724512 @default.
- W4313467575 cites W2409873653 @default.
- W4313467575 cites W2416032031 @default.
- W4313467575 cites W2436632490 @default.
- W4313467575 cites W2516952220 @default.
- W4313467575 cites W2525067819 @default.