Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313469891> ?p ?o ?g. }
- W4313469891 endingPage "27" @default.
- W4313469891 startingPage "27" @default.
- W4313469891 abstract "Olea europaea L. is a plant belonging to the Oleaceae family, widely grown around the Mediterranean Basin and its leaves are a source of phenolic compounds with antioxidant and anti-inflammatory capacity. Among these, oleuropein and luteolin-7-O-glucoside represent two major polyphenolic compounds in olive-leaf extract. Herein, a polystyrene resin was used to recover the polyphenolic fraction from the acetone-water leaf extract from Nocellara del Belice cultivar, which showed the higher level of analysed bioactive compounds, compared to Carolea cultivar. The antioxidant activity of the extract concentrated in phenolic compounds (OLECp) was evaluated through a classical assay and electron paramagnetic resonance (EPR) for DPPH and hydroxyl radicals scavenging. Thus, the anti-inflammatory activity and the potential beneficial effects in reducing lipid accumulation in an in vitro model of NAFLD using McA-RH7777 cells exposed to oleic acid (OA) were evaluated. Nile Red and Oil Red O have been used to stain the lipid accumulation, while the inflammatory status was assessed by Cytokines Bioplex Assay. OLECp (TPC: 92.93 ± 9.35 mg GAE/g, TFC: 728.12 ± 16.04 mg RE/g; 1 g of extract contains 315.250 mg of oleuropein and 17.44 mg of luteolin-7-O-glucoside) exerted a good radical scavenging capability (IC50: 2.30 ± 0.18 mg/mL) with a neutralizing power against DPPH and hydroxyl radicals, as confirmed by the decreased signal area of the EPR spectra. Moreover, OLECp at concentration of 25, 50 and 100 μg/mL counteracted the intracellular inflammatory status, as result of decreased intracellular lipid content. Our results highlighted the multiple properties and applications of an O. europaea extract concentrated in polyphenols, and the possibility to formulate novel nutraceuticals with antioxidant properties, destined to ameliorate human health." @default.
- W4313469891 created "2023-01-06" @default.
- W4313469891 creator A5006053315 @default.
- W4313469891 creator A5008645721 @default.
- W4313469891 creator A5021109233 @default.
- W4313469891 creator A5045505516 @default.
- W4313469891 creator A5046208546 @default.
- W4313469891 creator A5049086897 @default.
- W4313469891 creator A5049200791 @default.
- W4313469891 creator A5050263790 @default.
- W4313469891 creator A5062881112 @default.
- W4313469891 creator A5063304083 @default.
- W4313469891 creator A5069260907 @default.
- W4313469891 creator A5070957587 @default.
- W4313469891 creator A5071127556 @default.
- W4313469891 creator A5081979403 @default.
- W4313469891 creator A5085426785 @default.
- W4313469891 creator A5088103468 @default.
- W4313469891 date "2022-12-21" @default.
- W4313469891 modified "2023-10-15" @default.
- W4313469891 title "Nocellara Del Belice (Olea europaea L. Cultivar): Leaf Extract Concentrated in Phenolic Compounds and Its Anti-Inflammatory and Radical Scavenging Activity" @default.
- W4313469891 cites W1019169857 @default.
- W4313469891 cites W1485528518 @default.
- W4313469891 cites W1535746632 @default.
- W4313469891 cites W1855731201 @default.
- W4313469891 cites W1892729312 @default.
- W4313469891 cites W1954576972 @default.
- W4313469891 cites W1963616233 @default.
- W4313469891 cites W1972155313 @default.
- W4313469891 cites W1980774521 @default.
- W4313469891 cites W1982825156 @default.
- W4313469891 cites W1985431229 @default.
- W4313469891 cites W1991334358 @default.
- W4313469891 cites W1993156907 @default.
- W4313469891 cites W1993857808 @default.
- W4313469891 cites W2001436485 @default.
- W4313469891 cites W2004455022 @default.
- W4313469891 cites W2007071754 @default.
- W4313469891 cites W2022410074 @default.
- W4313469891 cites W2037504970 @default.
- W4313469891 cites W2061889437 @default.
- W4313469891 cites W2063989843 @default.
- W4313469891 cites W2067740038 @default.
- W4313469891 cites W2087117163 @default.
- W4313469891 cites W2091825504 @default.
- W4313469891 cites W2095864849 @default.
- W4313469891 cites W2100507276 @default.
- W4313469891 cites W2104511019 @default.
- W4313469891 cites W2108552132 @default.
- W4313469891 cites W2125454118 @default.
- W4313469891 cites W2136188494 @default.
- W4313469891 cites W2147629643 @default.
- W4313469891 cites W2166284674 @default.
- W4313469891 cites W2422255637 @default.
- W4313469891 cites W2468886892 @default.
- W4313469891 cites W2471898040 @default.
- W4313469891 cites W2566800732 @default.
- W4313469891 cites W2582061889 @default.
- W4313469891 cites W2593437180 @default.
- W4313469891 cites W2600157301 @default.
- W4313469891 cites W2623375388 @default.
- W4313469891 cites W2632741127 @default.
- W4313469891 cites W2741558090 @default.
- W4313469891 cites W2763137057 @default.
- W4313469891 cites W2797256710 @default.
- W4313469891 cites W2797479291 @default.
- W4313469891 cites W2800316525 @default.
- W4313469891 cites W2802621137 @default.
- W4313469891 cites W2807183240 @default.
- W4313469891 cites W2807212709 @default.
- W4313469891 cites W2810176575 @default.
- W4313469891 cites W2884439644 @default.
- W4313469891 cites W2887109450 @default.
- W4313469891 cites W2890249495 @default.
- W4313469891 cites W2893731608 @default.
- W4313469891 cites W2894503680 @default.
- W4313469891 cites W2895438350 @default.
- W4313469891 cites W2898263879 @default.
- W4313469891 cites W2901741192 @default.
- W4313469891 cites W2902661250 @default.
- W4313469891 cites W2903648166 @default.
- W4313469891 cites W2910137233 @default.
- W4313469891 cites W2911431753 @default.
- W4313469891 cites W2945695042 @default.
- W4313469891 cites W2945953380 @default.
- W4313469891 cites W2952774214 @default.
- W4313469891 cites W2956184864 @default.
- W4313469891 cites W2956907528 @default.
- W4313469891 cites W2980640943 @default.
- W4313469891 cites W2989949693 @default.
- W4313469891 cites W2990751432 @default.
- W4313469891 cites W2991394127 @default.
- W4313469891 cites W2998632462 @default.
- W4313469891 cites W3000578645 @default.
- W4313469891 cites W3005431503 @default.
- W4313469891 cites W3005675071 @default.
- W4313469891 cites W3009449523 @default.
- W4313469891 cites W3015919956 @default.