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- W4313470167 abstract "Cell death is a fundamental pathophysiological process in human disease. The discovery of necroptosis, a form of regulated necrosis that is induced by the activation of death receptors and formation of necrosome, represents a major breakthrough in the field of cell death in the past decade. Z-DNA-binding protein (ZBP1) is an interferon (IFN)-inducing protein, initially reported as a double-stranded DNA (dsDNA) sensor, which induces an innate inflammatory response. Recently, ZBP1 was identified as an important sensor of necroptosis during virus infection. It connects viral nucleic acid and receptor-interacting protein kinase 3 (RIPK3) via two domains and induces the formation of a necrosome. Recent studies have also reported that ZBP1 induces necroptosis in non-viral infections and mediates necrotic signal transduction by a unique mechanism. This review highlights the discovery of ZBP1 and its novel findings in necroptosis and provides an insight into its critical role in the crosstalk between different types of cell death, which may represent a new therapeutic option." @default.
- W4313470167 created "2023-01-06" @default.
- W4313470167 creator A5000561844 @default.
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- W4313470167 creator A5019451407 @default.
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- W4313470167 creator A5077807013 @default.
- W4313470167 creator A5091456610 @default.
- W4313470167 date "2022-12-21" @default.
- W4313470167 modified "2023-09-23" @default.
- W4313470167 title "ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications" @default.
- W4313470167 cites W1537667127 @default.
- W4313470167 cites W1552311056 @default.
- W4313470167 cites W1588312796 @default.
- W4313470167 cites W1972784467 @default.
- W4313470167 cites W1977099212 @default.
- W4313470167 cites W1980176492 @default.
- W4313470167 cites W1988969017 @default.
- W4313470167 cites W1993613360 @default.
- W4313470167 cites W2005138952 @default.
- W4313470167 cites W2005928313 @default.
- W4313470167 cites W2006273251 @default.
- W4313470167 cites W2008741758 @default.
- W4313470167 cites W2008757142 @default.
- W4313470167 cites W2015532987 @default.
- W4313470167 cites W2028792773 @default.
- W4313470167 cites W2033783426 @default.
- W4313470167 cites W2043343078 @default.
- W4313470167 cites W2052853635 @default.
- W4313470167 cites W2060094569 @default.
- W4313470167 cites W2072540607 @default.
- W4313470167 cites W2077490715 @default.
- W4313470167 cites W2084414744 @default.
- W4313470167 cites W2101698988 @default.
- W4313470167 cites W2108286247 @default.
- W4313470167 cites W2116428280 @default.
- W4313470167 cites W2118038164 @default.
- W4313470167 cites W2118053403 @default.
- W4313470167 cites W2127684626 @default.
- W4313470167 cites W2130603600 @default.
- W4313470167 cites W2133402546 @default.
- W4313470167 cites W2133669258 @default.
- W4313470167 cites W2134295452 @default.
- W4313470167 cites W2138686425 @default.
- W4313470167 cites W2139552156 @default.
- W4313470167 cites W2291601731 @default.
- W4313470167 cites W2468375317 @default.
- W4313470167 cites W2473351606 @default.
- W4313470167 cites W2478313696 @default.
- W4313470167 cites W2507605260 @default.
- W4313470167 cites W2530130883 @default.
- W4313470167 cites W2536357747 @default.
- W4313470167 cites W2547118804 @default.
- W4313470167 cites W2547911415 @default.
- W4313470167 cites W2560541542 @default.
- W4313470167 cites W2573286366 @default.
- W4313470167 cites W2589060305 @default.
- W4313470167 cites W2610420640 @default.
- W4313470167 cites W2622955470 @default.
- W4313470167 cites W2700322240 @default.
- W4313470167 cites W2734686459 @default.
- W4313470167 cites W2736148366 @default.
- W4313470167 cites W2750745925 @default.
- W4313470167 cites W2762118399 @default.
- W4313470167 cites W2783080528 @default.
- W4313470167 cites W2783228241 @default.
- W4313470167 cites W2791998267 @default.
- W4313470167 cites W2883756825 @default.
- W4313470167 cites W2895833591 @default.
- W4313470167 cites W2902231393 @default.
- W4313470167 cites W2907794526 @default.
- W4313470167 cites W2944388007 @default.
- W4313470167 cites W2946520149 @default.
- W4313470167 cites W2950532812 @default.
- W4313470167 cites W2951344798 @default.
- W4313470167 cites W2953275535 @default.
- W4313470167 cites W2957274822 @default.
- W4313470167 cites W2964867945 @default.
- W4313470167 cites W2972960041 @default.
- W4313470167 cites W2976299346 @default.
- W4313470167 cites W2980844705 @default.
- W4313470167 cites W2981397129 @default.
- W4313470167 cites W2991204446 @default.
- W4313470167 cites W2993119172 @default.
- W4313470167 cites W2995981280 @default.
- W4313470167 cites W2998122367 @default.
- W4313470167 cites W2999984340 @default.
- W4313470167 cites W3011113661 @default.
- W4313470167 cites W3012172246 @default.
- W4313470167 cites W3013796529 @default.
- W4313470167 cites W3016413841 @default.
- W4313470167 cites W3017229457 @default.
- W4313470167 cites W3022225042 @default.
- W4313470167 cites W3023862641 @default.