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- W4313471355 abstract "Polygonum multiflorum Thunb. (PMT), a commonly used Chinese herbal medicine for treating diseases such as poisoning and white hair, has attracted constant attention due to the frequent occurrence of liver injury incidents. To date, its hepatotoxic equivalent markers (HEMs) and potential hepatotoxic mechanisms are still unclear. In order to clarify the HEMs of PMT and further explore the potential mechanisms of hepatotoxicity, firstly, the chemical constituents in PMT extract were globally characterized, and the fingerprints of PMT extracts were established along with the detection of their hepatotoxicity in vivo. Then, the correlations between hepatotoxic features and component contents were modeled by chemometrics to screen HEMs of PMT, which were then further evaluated. Finally, the hepatotoxic mechanisms of PMT were investigated using liver metabolomics and molecular docking. The results show that the chemical combination of 2,3,5,4-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) and emodin-8-O-glucoside (EG) was discovered as the HEMs of PMT through pre-screening and verifying process. Liver metabolomics revealed that PMT caused liver injury by interfering with purine metabolism, which might be related to mitochondrial function disorder and oxidative injury via the up-regulations of xanthosine and xanthine, and the down-regulation of 5' nucleotidase (NT5E) and adenylate kinase 2 (AK2). This study not only found that the HEMs of PMT were TSG and EG, but also clarified that PMT might affect purine metabolism to induce liver injury, which contributed to our understanding of the underlying mechanisms of PMT hepatotoxicity." @default.
- W4313471355 created "2023-01-06" @default.
- W4313471355 creator A5013070913 @default.
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- W4313471355 creator A5078852095 @default.
- W4313471355 creator A5083047932 @default.
- W4313471355 creator A5085816631 @default.
- W4313471355 date "2022-12-21" @default.
- W4313471355 modified "2023-09-26" @default.
- W4313471355 title "Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking" @default.
- W4313471355 cites W1509222074 @default.
- W4313471355 cites W1543030743 @default.
- W4313471355 cites W1597285948 @default.
- W4313471355 cites W1681947033 @default.
- W4313471355 cites W1755717066 @default.
- W4313471355 cites W1860370624 @default.
- W4313471355 cites W1914280947 @default.
- W4313471355 cites W1974409640 @default.
- W4313471355 cites W1982185581 @default.
- W4313471355 cites W1982320452 @default.
- W4313471355 cites W1982794760 @default.
- W4313471355 cites W1985039493 @default.
- W4313471355 cites W1986240377 @default.
- W4313471355 cites W1986375719 @default.
- W4313471355 cites W1990194768 @default.
- W4313471355 cites W1990703634 @default.
- W4313471355 cites W1992869484 @default.
- W4313471355 cites W2012068646 @default.
- W4313471355 cites W2014245551 @default.
- W4313471355 cites W2025701648 @default.
- W4313471355 cites W2034764339 @default.
- W4313471355 cites W2041292257 @default.
- W4313471355 cites W2043884208 @default.
- W4313471355 cites W2045754603 @default.
- W4313471355 cites W2047637108 @default.
- W4313471355 cites W2054508985 @default.
- W4313471355 cites W2071064091 @default.
- W4313471355 cites W2074874578 @default.
- W4313471355 cites W2076204761 @default.
- W4313471355 cites W2077102596 @default.
- W4313471355 cites W2082783398 @default.
- W4313471355 cites W2082849942 @default.
- W4313471355 cites W2084035112 @default.
- W4313471355 cites W2086556660 @default.
- W4313471355 cites W2090368102 @default.
- W4313471355 cites W2091326460 @default.
- W4313471355 cites W2095988220 @default.
- W4313471355 cites W2096173332 @default.
- W4313471355 cites W2126949712 @default.
- W4313471355 cites W2135308053 @default.
- W4313471355 cites W2136336812 @default.
- W4313471355 cites W2138793275 @default.
- W4313471355 cites W2145071581 @default.
- W4313471355 cites W2150994390 @default.
- W4313471355 cites W2151070736 @default.
- W4313471355 cites W2152964937 @default.
- W4313471355 cites W2215132799 @default.
- W4313471355 cites W2280603171 @default.
- W4313471355 cites W229058249 @default.
- W4313471355 cites W2346363346 @default.
- W4313471355 cites W2347063413 @default.
- W4313471355 cites W2411100545 @default.
- W4313471355 cites W2416252252 @default.
- W4313471355 cites W2417452665 @default.
- W4313471355 cites W2426071366 @default.
- W4313471355 cites W2468966126 @default.
- W4313471355 cites W2519695247 @default.
- W4313471355 cites W2527180091 @default.
- W4313471355 cites W2548514080 @default.
- W4313471355 cites W2554735043 @default.
- W4313471355 cites W2567709207 @default.
- W4313471355 cites W2596565027 @default.
- W4313471355 cites W2599869888 @default.
- W4313471355 cites W2652430319 @default.
- W4313471355 cites W2743629181 @default.
- W4313471355 cites W2761245997 @default.
- W4313471355 cites W2781647229 @default.
- W4313471355 cites W2802937446 @default.
- W4313471355 cites W2805539079 @default.
- W4313471355 cites W2810069808 @default.
- W4313471355 cites W2881440280 @default.
- W4313471355 cites W2885582458 @default.
- W4313471355 cites W2922846941 @default.
- W4313471355 cites W2935824953 @default.
- W4313471355 cites W2945673523 @default.
- W4313471355 cites W2960020042 @default.
- W4313471355 cites W2982690628 @default.
- W4313471355 cites W2993929116 @default.
- W4313471355 cites W2994072336 @default.
- W4313471355 cites W3012584785 @default.