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• W4313471383 endingPage "58" @default.
• W4313471383 startingPage "58" @default.
• W4313471383 abstract "Psychotropic effect of Crocus sativus L. (family Iridaceae) biologically active chemical compounds are quite well documented and they can therefore be used in addition to the conventional pharmacological treatment of depression. This systematic review on antidepressant compounds in saffron crocus and their mechanisms of action and side effects is based on publications released between 1995−2022 and data indexed in 15 databases under the following search terms: antidepressant effect, central nervous system, Crocus sativus, cognitive impairement, crocin, crocetin, depression, dopamine, dopaminergic and serotonergic systems, picrocrocin, phytotherapy, neurotransmitters, safranal, saffron, serotonin, and biologically active compounds. The comparative analysis of the publications was based on 414 original research papers. The investigated literature indicates the effectiveness and safety of aqueous and alcoholic extracts and biologically active chemical compounds (alkaloids, anthocyanins, carotenoids, flavonoid, phenolic, saponins, and terpenoids) isolated from various organs (corms, leaves, flower petal, and stigmas) in adjuvant treatment of depression and anxiety. Monoamine reuptake inhibition, N-methyl-d-aspartate (NMDA) receptor antagonism, and gamma-aminobutyric acid (GABA)-α agonism are the main proposed mechanism of the antidepressant action. The antidepressant and neuroprotective effect of extract components is associated with their anti-inflammatory and antioxidant activity. The mechanism of their action, interactions with conventional drugs and other herbal preparations and the safety of use are not fully understood; therefore, further detailed research in this field is necessary. The presented results regarding the application of C. sativus in phytotherapy are promising in terms of the use of herbal preparations to support the treatment of depression. This is particularly important given the steady increase in the incidence of this disease worldwide and social effects." @default.
• W4313471383 created "2023-01-06" @default.
• W4313471383 creator A5007701687 @default.
• W4313471383 creator A5017235651 @default.
• W4313471383 creator A5045030809 @default.
• W4313471383 creator A5045544106 @default.
• W4313471383 date "2022-12-30" @default.
• W4313471383 modified "2023-10-14" @default.
• W4313471383 title "Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L." @default.
• W4313471383 cites W133736196 @default.
• W4313471383 cites W1483936248 @default.
• W4313471383 cites W1534744253 @default.
• W4313471383 cites W1535110134 @default.
• W4313471383 cites W1549483541 @default.
• W4313471383 cites W1551506091 @default.
• W4313471383 cites W1588866580 @default.
• W4313471383 cites W1657355392 @default.
• W4313471383 cites W1835089804 @default.
• W4313471383 cites W1863901809 @default.
• W4313471383 cites W1868546265 @default.
• W4313471383 cites W1886996212 @default.
• W4313471383 cites W1911245840 @default.
• W4313471383 cites W1935427932 @default.
• W4313471383 cites W1935729620 @default.
• W4313471383 cites W1947883362 @default.
• W4313471383 cites W1950423950 @default.
• W4313471383 cites W1964416303 @default.
• W4313471383 cites W1965373007 @default.
• W4313471383 cites W1966503842 @default.
• W4313471383 cites W1967240735 @default.
• W4313471383 cites W1969973951 @default.
• W4313471383 cites W1976021000 @default.
• W4313471383 cites W1976176778 @default.
• W4313471383 cites W1977441999 @default.
• W4313471383 cites W1979461875 @default.
• W4313471383 cites W1981634698 @default.
• W4313471383 cites W1983746911 @default.
• W4313471383 cites W1984025057 @default.
• W4313471383 cites W1988632498 @default.
• W4313471383 cites W1988950261 @default.
• W4313471383 cites W1992456991 @default.
• W4313471383 cites W1994714011 @default.
• W4313471383 cites W1995959447 @default.
• W4313471383 cites W1996026559 @default.
• W4313471383 cites W1996041232 @default.
• W4313471383 cites W1997533350 @default.
• W4313471383 cites W1997719370 @default.
• W4313471383 cites W1999003500 @default.
• W4313471383 cites W2000995162 @default.
• W4313471383 cites W2002587169 @default.
• W4313471383 cites W2002834809 @default.
• W4313471383 cites W2003479485 @default.
• W4313471383 cites W2004635279 @default.
• W4313471383 cites W2005424649 @default.
• W4313471383 cites W2006643314 @default.
• W4313471383 cites W2007555728 @default.
• W4313471383 cites W2007856751 @default.
• W4313471383 cites W2014723937 @default.
• W4313471383 cites W2015861923 @default.
• W4313471383 cites W2016639113 @default.
• W4313471383 cites W2023453911 @default.
• W4313471383 cites W2024448645 @default.
• W4313471383 cites W2027381555 @default.
• W4313471383 cites W2029142628 @default.
• W4313471383 cites W2031168117 @default.
• W4313471383 cites W2032021469 @default.
• W4313471383 cites W2032922770 @default.
• W4313471383 cites W2034270403 @default.
• W4313471383 cites W2037426641 @default.
• W4313471383 cites W2039145008 @default.
• W4313471383 cites W2040306356 @default.
• W4313471383 cites W2040513770 @default.
• W4313471383 cites W2041237855 @default.
• W4313471383 cites W2042070961 @default.
• W4313471383 cites W2042123130 @default.
• W4313471383 cites W2043036577 @default.
• W4313471383 cites W2043563630 @default.
• W4313471383 cites W2044989620 @default.
• W4313471383 cites W2045312842 @default.
• W4313471383 cites W2046252840 @default.
• W4313471383 cites W2049725443 @default.
• W4313471383 cites W2050679620 @default.
• W4313471383 cites W2054437388 @default.
• W4313471383 cites W2055347004 @default.
• W4313471383 cites W2055651266 @default.
• W4313471383 cites W2059865440 @default.
• W4313471383 cites W2061037238 @default.
• W4313471383 cites W2068055929 @default.
• W4313471383 cites W2069240179 @default.
• W4313471383 cites W2069601103 @default.
• W4313471383 cites W2070871457 @default.
• W4313471383 cites W2072951436 @default.
• W4313471383 cites W2081830465 @default.
• W4313471383 cites W2082969652 @default.
• W4313471383 cites W2084319580 @default.
• W4313471383 cites W2085798653 @default.
• W4313471383 cites W2087946559 @default.
• W4313471383 cites W2088791250 @default.

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