FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313471606> ?p ?o ?g. }

• W4313471606 endingPage "26" @default.
• W4313471606 startingPage "26" @default.
• W4313471606 abstract "In recent decades, the use of herbs and plants has been of great interest, as they have been the sources of natural products, commonly named as bioactive compounds. In specific, the natural compounds from the Capparaceae family which has been proved to have antioxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities, by several studies. Cleome arabica L. (CA) specie is the most used medicinal plants in Tunisia and elsewhere in North African countries for treatment of various diseases including diabetes, rheumatism, inflammation, cancer, and digestive disorders. The current work was undertaken to estimate the total phenolic, flavonoid and condensed tannin contents, to identify and quantify the polyphenolic compounds, and to evaluate the antioxidant and the anti-inflammatory proprieties of CA fruits extract against formalin induced chronic inflammation in Female Wistar rats. In fact, the antioxidant activity was tested by Diphenyl-1-Picrylhydrazyl free radical scavenging (DPPH), Ferric reducing antioxidant power (FRAP) and Nitric Oxide radical (NO·). Anti-inflammatory effect of fruits extract was examined using formalin (2%) induced paw edema in rats. Molecular docking tools were used to investigate the interaction of some compounds from CA fruits extract with the cyclooxygenase-2 (COX-2) target protein. Our results showed that, the total phenolic, flavonoid and tannins contents, which were assessed by the Folin-Ciocalteu, Quercetin, and Catechin methods, respectively, were 230.22 mg gallic acid equivalent/g dry weight (mg GAE/g DW), 55.08 mg quercetin equivalent/g dry weight (QE/g DW) and 15.17 mg catechin equivalents/g dry weight (CatE/g DW), respectively. HPLC analysis revealed the presence of five polyphenolic compounds whose catechin was found to be the most abundant compounds. The antioxidant activity of extract was quantified by DPPH, FRAP and NO· tests and IC50 reached the values of 3.346 mg/mL, 2.306 and 0.023 mg/mL, respectively. Cleome fruits ameliorated the histological integrity of the skin and alleviated the disruptions in hematological parameters (WBC, LYM, RBC, and HGB), inflammatory cytokines (IL-1β, IL-6, TNF-α), C-reactive protein, and some oxidative stress markers (TBARS (-49%) and AOPP (-42%) levels, SOD (+33%) and GPx (+75%) activities, and GSH (+49%) content) induced by formalin injection. Moreover, the in-silico investigation had shown that CA fruits extract compounds have a stronger interaction with COX-2 active site, more than the reference drug indomethacin (two H-bonds). Our research gives pharmacological backing to the healthcare utilization of Cleome plant in the treatment of inflammatory diseases and oxidative harm." @default.
• W4313471606 created "2023-01-06" @default.
• W4313471606 creator A5000877206 @default.
• W4313471606 creator A5002597249 @default.
• W4313471606 creator A5020335265 @default.
• W4313471606 creator A5027953723 @default.
• W4313471606 creator A5042148573 @default.
• W4313471606 creator A5050602085 @default.
• W4313471606 creator A5051315234 @default.
• W4313471606 creator A5052594623 @default.
• W4313471606 creator A5055223563 @default.
• W4313471606 creator A5067286919 @default.
• W4313471606 creator A5076509614 @default.
• W4313471606 creator A5087692117 @default.
• W4313471606 date "2022-12-21" @default.
• W4313471606 modified "2023-10-18" @default.
• W4313471606 title "Phytochemical Characterization, Antioxidant and Anti-Inflammatory Effects of Cleome arabica L. Fruits Extract against Formalin Induced Chronic Inflammation in Female Wistar Rat: Biochemical, Histological, and In Silico Studies" @default.
• W4313471606 cites W1546592314 @default.
• W4313471606 cites W1575211640 @default.
• W4313471606 cites W1775749144 @default.
• W4313471606 cites W1854010492 @default.
• W4313471606 cites W1921050281 @default.
• W4313471606 cites W1976501012 @default.
• W4313471606 cites W1977748675 @default.
• W4313471606 cites W1977976534 @default.
• W4313471606 cites W1978500409 @default.
• W4313471606 cites W1988073619 @default.
• W4313471606 cites W1990802251 @default.
• W4313471606 cites W1994393334 @default.
• W4313471606 cites W1996060562 @default.
• W4313471606 cites W2004079184 @default.
• W4313471606 cites W2004121099 @default.
• W4313471606 cites W2015466667 @default.
• W4313471606 cites W2021995332 @default.
• W4313471606 cites W2032949584 @default.
• W4313471606 cites W2042641359 @default.
• W4313471606 cites W2050480840 @default.
• W4313471606 cites W2062447674 @default.
• W4313471606 cites W2068791745 @default.
• W4313471606 cites W2071866695 @default.
• W4313471606 cites W2079372280 @default.
• W4313471606 cites W2080040601 @default.
• W4313471606 cites W2086122328 @default.
• W4313471606 cites W2101422765 @default.
• W4313471606 cites W2112845321 @default.
• W4313471606 cites W2134967712 @default.
• W4313471606 cites W2136912731 @default.
• W4313471606 cites W2142859461 @default.
• W4313471606 cites W2146346788 @default.
• W4313471606 cites W2152569470 @default.
• W4313471606 cites W2165966968 @default.
• W4313471606 cites W2167937185 @default.
• W4313471606 cites W2404973556 @default.
• W4313471606 cites W2405145432 @default.
• W4313471606 cites W2418136280 @default.
• W4313471606 cites W2486507305 @default.
• W4313471606 cites W2530673166 @default.
• W4313471606 cites W2560975670 @default.
• W4313471606 cites W2604929125 @default.
• W4313471606 cites W2760033459 @default.
• W4313471606 cites W2786102010 @default.
• W4313471606 cites W2790062274 @default.
• W4313471606 cites W2792789258 @default.
• W4313471606 cites W2793640449 @default.
• W4313471606 cites W2798105113 @default.
• W4313471606 cites W2804766311 @default.
• W4313471606 cites W2883664407 @default.
• W4313471606 cites W2894779213 @default.
• W4313471606 cites W2941517103 @default.
• W4313471606 cites W2951548644 @default.
• W4313471606 cites W2956635503 @default.
• W4313471606 cites W2959497269 @default.
• W4313471606 cites W3005030564 @default.
• W4313471606 cites W3006434445 @default.
• W4313471606 cites W3007465172 @default.
• W4313471606 cites W3036732619 @default.
• W4313471606 cites W3040990163 @default.
• W4313471606 cites W3043380509 @default.
• W4313471606 cites W3082590213 @default.
• W4313471606 cites W3096758564 @default.
• W4313471606 cites W3119966018 @default.
• W4313471606 cites W3124459948 @default.
• W4313471606 cites W3132177504 @default.
• W4313471606 cites W3150156701 @default.
• W4313471606 cites W3156035806 @default.
• W4313471606 cites W3172093692 @default.
• W4313471606 cites W3172737753 @default.
• W4313471606 cites W3174985249 @default.
• W4313471606 cites W3191550608 @default.
• W4313471606 cites W3196668625 @default.
• W4313471606 cites W3201527174 @default.
• W4313471606 cites W3212685958 @default.
• W4313471606 cites W3213158237 @default.
• W4313471606 cites W3214698193 @default.
• W4313471606 cites W4281565771 @default.
• W4313471606 cites W4289537408 @default.
• W4313471606 cites W4296830556 @default.
• W4313471606 doi "https://doi.org/10.3390/molecules28010026" @default.

• next