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- W4313472145 abstract "Renal cell carcinoma (RCC) makes up the majority of kidney cancers, with a poor prognosis for metastatic RCC (mRCC). Challenges faced in the management of mRCC, include a lack of reliable prognostic markers and biomarkers for precise monitoring of disease treatment, together with the potential risk of toxicity associated with more recent therapeutic options. Glycosaminoglycans (GAGs) are a class of carbohydrates that can be categorized into four main subclasses, viz., chondroitin sulfate, hyaluronic acid, heparan sulfate and keratan sulfate. GAGs are known to be closely associated with cancer progression and modulation of metastasis by modification of the tumor microenvironment. Alterations of expression, composition and spatiotemporal distribution of GAGs in the extracellular matrix (ECM), dysregulate ECM functions and drive cancer invasion. In this review, we focus on the clinical utility of GAGs as biomarkers for mRCC (which is important for risk stratification and strategizing effective treatment protocols), as well as potential therapeutic targets that could benefit patients afflicted with advanced RCC. Besides GAG-targeted therapies that holds promise in mRCC, other potential strategies include utilizing GAGs as drug carriers and their mimetics to counter cancer progression, and enhance immunotherapy through binding and transducing signals for immune mediators." @default.
- W4313472145 created "2023-01-06" @default.
- W4313472145 creator A5042485417 @default.
- W4313472145 creator A5078369408 @default.
- W4313472145 creator A5085739072 @default.
- W4313472145 creator A5091560850 @default.
- W4313472145 date "2022-12-30" @default.
- W4313472145 modified "2023-10-14" @default.
- W4313472145 title "Theranostic Applications of Glycosaminoglycans in Metastatic Renal Cell Carcinoma" @default.
- W4313472145 cites W1507411181 @default.
- W4313472145 cites W1522174324 @default.
- W4313472145 cites W1558905924 @default.
- W4313472145 cites W1590331501 @default.
- W4313472145 cites W1647207353 @default.
- W4313472145 cites W1771887010 @default.
- W4313472145 cites W1882002483 @default.
- W4313472145 cites W1896781151 @default.
- W4313472145 cites W1922967720 @default.
- W4313472145 cites W1966595575 @default.
- W4313472145 cites W1970733468 @default.
- W4313472145 cites W1971222243 @default.
- W4313472145 cites W1971971965 @default.
- W4313472145 cites W1976237200 @default.
- W4313472145 cites W1979009164 @default.
- W4313472145 cites W1986057432 @default.
- W4313472145 cites W1987748916 @default.
- W4313472145 cites W1989337644 @default.
- W4313472145 cites W1993534896 @default.
- W4313472145 cites W1996544895 @default.
- W4313472145 cites W1998000133 @default.
- W4313472145 cites W1999966467 @default.
- W4313472145 cites W2001790577 @default.
- W4313472145 cites W2004105893 @default.
- W4313472145 cites W2007486148 @default.
- W4313472145 cites W2008581828 @default.
- W4313472145 cites W2009930793 @default.
- W4313472145 cites W2014449340 @default.
- W4313472145 cites W2014614460 @default.
- W4313472145 cites W2021089210 @default.
- W4313472145 cites W2022243451 @default.
- W4313472145 cites W2023026872 @default.
- W4313472145 cites W2028307915 @default.
- W4313472145 cites W2030605936 @default.
- W4313472145 cites W2032025349 @default.
- W4313472145 cites W2032610111 @default.
- W4313472145 cites W2034384394 @default.
- W4313472145 cites W2035420579 @default.
- W4313472145 cites W2035536358 @default.
- W4313472145 cites W2040504273 @default.
- W4313472145 cites W2047534454 @default.
- W4313472145 cites W2049455929 @default.
- W4313472145 cites W2055091294 @default.
- W4313472145 cites W2058229406 @default.
- W4313472145 cites W2058873998 @default.
- W4313472145 cites W2059236876 @default.
- W4313472145 cites W2060348227 @default.
- W4313472145 cites W2060529002 @default.
- W4313472145 cites W2060559986 @default.
- W4313472145 cites W2061444420 @default.
- W4313472145 cites W2063621230 @default.
- W4313472145 cites W2065939980 @default.
- W4313472145 cites W2066604995 @default.
- W4313472145 cites W2066911929 @default.
- W4313472145 cites W2068017580 @default.
- W4313472145 cites W2069701490 @default.
- W4313472145 cites W2070503172 @default.
- W4313472145 cites W2073257185 @default.
- W4313472145 cites W2075905225 @default.
- W4313472145 cites W2080442263 @default.
- W4313472145 cites W2084580461 @default.
- W4313472145 cites W2084862813 @default.
- W4313472145 cites W2085665189 @default.
- W4313472145 cites W2088128469 @default.
- W4313472145 cites W2089542655 @default.
- W4313472145 cites W2090448290 @default.
- W4313472145 cites W2093105418 @default.
- W4313472145 cites W2094247940 @default.
- W4313472145 cites W2094665308 @default.
- W4313472145 cites W2097674841 @default.
- W4313472145 cites W2102619165 @default.
- W4313472145 cites W2104512411 @default.
- W4313472145 cites W2104692426 @default.
- W4313472145 cites W2106144394 @default.
- W4313472145 cites W2107109133 @default.
- W4313472145 cites W2117692326 @default.
- W4313472145 cites W2118121278 @default.
- W4313472145 cites W2120717826 @default.
- W4313472145 cites W2121076289 @default.
- W4313472145 cites W2121179180 @default.
- W4313472145 cites W2121317031 @default.
- W4313472145 cites W2121821154 @default.
- W4313472145 cites W2127059375 @default.
- W4313472145 cites W2130464657 @default.
- W4313472145 cites W2130725713 @default.
- W4313472145 cites W2134131507 @default.
- W4313472145 cites W2134525336 @default.
- W4313472145 cites W2135325995 @default.
- W4313472145 cites W2136767914 @default.