FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313472189> ?p ?o ?g. }

• W4313472189 endingPage "256" @default.
• W4313472189 startingPage "256" @default.
• W4313472189 abstract "To overcome the lack of specificity of cancer therapeutics and thus create a more potent and effective treatment, we developed a novel chimeric protein, IL2-Smurf2. Here, we describe the production of this chimeric IL2-Smurf2 protein and its variants, with inactive or over-active killing components. Using Western blots, we demonstrated the chimeric protein's ability to specifically enter target cells alone. After entering the cells, the protein showed biological activity, causing cell death that was not seen with an inactive variant, and that was shown to be apoptotic. The chimeric protein also proved to be active as an E3 ligase, as demonstrated by testing total ubiquitination levels along with targeted ubiquitination for degradation. Finally, we tested IL2-Smurf2 and its variants in an in vivo mouse model of leukemia and demonstrated its potential as a drug for the targeted treatment of cancer cells. In the course of this work, we established for the first time the feasibility of the use of Smurf2 as a killing component in chimeric targeting proteins. Utilizing the IL2 cytokine to target cells overexpressing IL-2R and Smurf2 to cause protein degradation, we were able to produce a chimeric protein with dual functionality which causes targeted cell death." @default.
• W4313472189 created "2023-01-06" @default.
• W4313472189 creator A5033423836 @default.
• W4313472189 creator A5039290438 @default.
• W4313472189 creator A5039775811 @default.
• W4313472189 creator A5042395201 @default.
• W4313472189 creator A5050331442 @default.
• W4313472189 creator A5070977170 @default.
• W4313472189 date "2022-12-30" @default.
• W4313472189 modified "2023-10-05" @default.
• W4313472189 title "Exploiting the Endogenous Ubiquitin Proteasome System in Targeted Cancer Treatment" @default.
• W4313472189 cites W1519258930 @default.
• W4313472189 cites W1913780655 @default.
• W4313472189 cites W1967046030 @default.
• W4313472189 cites W1977490774 @default.
• W4313472189 cites W1977890006 @default.
• W4313472189 cites W1991714991 @default.
• W4313472189 cites W1993051112 @default.
• W4313472189 cites W1993803613 @default.
• W4313472189 cites W1996468220 @default.
• W4313472189 cites W2005871152 @default.
• W4313472189 cites W2007093894 @default.
• W4313472189 cites W2007324489 @default.
• W4313472189 cites W2013339424 @default.
• W4313472189 cites W2035272997 @default.
• W4313472189 cites W2042128990 @default.
• W4313472189 cites W2057230999 @default.
• W4313472189 cites W2059779437 @default.
• W4313472189 cites W2062019417 @default.
• W4313472189 cites W2062348697 @default.
• W4313472189 cites W2063090066 @default.
• W4313472189 cites W2066612343 @default.
• W4313472189 cites W2067343115 @default.
• W4313472189 cites W2077228061 @default.
• W4313472189 cites W2092101339 @default.
• W4313472189 cites W2099264111 @default.
• W4313472189 cites W2126840542 @default.
• W4313472189 cites W2128635872 @default.
• W4313472189 cites W2133811759 @default.
• W4313472189 cites W2147917253 @default.
• W4313472189 cites W2156201868 @default.
• W4313472189 cites W2166987747 @default.
• W4313472189 cites W2509042913 @default.
• W4313472189 cites W2697775881 @default.
• W4313472189 cites W2734356283 @default.
• W4313472189 cites W2741466148 @default.
• W4313472189 cites W2892039698 @default.
• W4313472189 cites W2996923341 @default.
• W4313472189 cites W3015903104 @default.
• W4313472189 cites W3085123053 @default.
• W4313472189 cites W3134655285 @default.
• W4313472189 cites W3135599985 @default.
• W4313472189 cites W3136328381 @default.
• W4313472189 cites W3177828909 @default.
• W4313472189 cites W3195333672 @default.
• W4313472189 cites W338483294 @default.
• W4313472189 cites W34432408 @default.
• W4313472189 cites W4200252581 @default.
• W4313472189 cites W4226329559 @default.
• W4313472189 cites W4293247451 @default.
• W4313472189 cites W4294127789 @default.
• W4313472189 doi "https://doi.org/10.3390/cancers15010256" @default.
• W4313472189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36612252" @default.
• W4313472189 hasPublicationYear "2022" @default.
• W4313472189 type Work @default.
• W4313472189 citedByCount "0" @default.
• W4313472189 crossrefType "journal-article" @default.
• W4313472189 hasAuthorship W4313472189A5033423836 @default.
• W4313472189 hasAuthorship W4313472189A5039290438 @default.
• W4313472189 hasAuthorship W4313472189A5039775811 @default.
• W4313472189 hasAuthorship W4313472189A5042395201 @default.
• W4313472189 hasAuthorship W4313472189A5050331442 @default.
• W4313472189 hasAuthorship W4313472189A5070977170 @default.
• W4313472189 hasBestOaLocation W43134721891 @default.
• W4313472189 hasConcept C104317684 @default.
• W4313472189 hasConcept C121608353 @default.
• W4313472189 hasConcept C123894998 @default.
• W4313472189 hasConcept C134459356 @default.
• W4313472189 hasConcept C185592680 @default.
• W4313472189 hasConcept C25602115 @default.
• W4313472189 hasConcept C27740335 @default.
• W4313472189 hasConcept C2780430158 @default.
• W4313472189 hasConcept C2992195973 @default.
• W4313472189 hasConcept C40767141 @default.
• W4313472189 hasConcept C502942594 @default.
• W4313472189 hasConcept C54355233 @default.
• W4313472189 hasConcept C55493867 @default.
• W4313472189 hasConcept C86803240 @default.
• W4313472189 hasConcept C95444343 @default.
• W4313472189 hasConcept C96232424 @default.
• W4313472189 hasConceptScore W4313472189C104317684 @default.
• W4313472189 hasConceptScore W4313472189C121608353 @default.
• W4313472189 hasConceptScore W4313472189C123894998 @default.
• W4313472189 hasConceptScore W4313472189C134459356 @default.
• W4313472189 hasConceptScore W4313472189C185592680 @default.
• W4313472189 hasConceptScore W4313472189C25602115 @default.
• W4313472189 hasConceptScore W4313472189C27740335 @default.
• W4313472189 hasConceptScore W4313472189C2780430158 @default.

• next