FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313472238> ?p ?o ?g. }

• W4313472238 endingPage "124" @default.
• W4313472238 startingPage "124" @default.
• W4313472238 abstract "Foot-and-mouth disease virus (FMDV), an economically important pathogen of cloven-hoofed livestock, is a positive-sense, single-stranded RNA virus classified in the Picornaviridae family. RNA-dependent RNA polymerase (RdRp) of RNA viruses is highly conserved. Compounds that bind to the RdRp active site can block viral replication. Herein, we combined double virtual screenings and cell-based antiviral approaches to screen and identify potential inhibitors targeting FMDV RdRp (3Dpol). From 5596 compounds, the blind- followed by focus-docking filtered 21 candidates fitting in the 3Dpol active sites. Using the BHK-21 cell-based assay, we found that four compounds-NSC217697 (quinoline), NSC670283 (spiro compound), NSC292567 (nigericin), and NSC65850-demonstrated dose-dependent antiviral actions in vitro with the EC50 ranging from 0.78 to 3.49 µM. These compounds could significantly block FMDV 3Dpol activity in the cell-based 3Dpol inhibition assay with small IC50 values ranging from 0.8 nM to 0.22 µM without an effect on FMDV's main protease, 3Cpro. The 3Dpol inhibition activities of the compounds were consistent with the decreased viral load and negative-stranded RNA production in a dose-dependent manner. Conclusively, we have identified potential FMDV 3Dpol inhibitors that bound within the enzyme active sites and blocked viral replication. These compounds might be beneficial for FMDV or other picornavirus treatment." @default.
• W4313472238 created "2023-01-06" @default.
• W4313472238 creator A5013871287 @default.
• W4313472238 creator A5016326721 @default.
• W4313472238 creator A5030520632 @default.
• W4313472238 creator A5035466026 @default.
• W4313472238 creator A5063205557 @default.
• W4313472238 creator A5084503488 @default.
• W4313472238 date "2022-12-30" @default.
• W4313472238 modified "2023-10-14" @default.
• W4313472238 title "Non-Nucleoside Inhibitors Decrease Foot-and-Mouth Disease Virus Replication by Blocking the Viral 3Dpol" @default.
• W4313472238 cites W1887624773 @default.
• W4313472238 cites W1967589025 @default.
• W4313472238 cites W1971849220 @default.
• W4313472238 cites W1975354443 @default.
• W4313472238 cites W1995568450 @default.
• W4313472238 cites W1998617962 @default.
• W4313472238 cites W2009178147 @default.
• W4313472238 cites W2023797639 @default.
• W4313472238 cites W2026864338 @default.
• W4313472238 cites W2030140637 @default.
• W4313472238 cites W2035551330 @default.
• W4313472238 cites W2044105167 @default.
• W4313472238 cites W2061463182 @default.
• W4313472238 cites W2089561176 @default.
• W4313472238 cites W2095250339 @default.
• W4313472238 cites W2110670926 @default.
• W4313472238 cites W2125923988 @default.
• W4313472238 cites W2126589642 @default.
• W4313472238 cites W2129577287 @default.
• W4313472238 cites W2134967712 @default.
• W4313472238 cites W2142530861 @default.
• W4313472238 cites W2154714625 @default.
• W4313472238 cites W2159614853 @default.
• W4313472238 cites W2168795142 @default.
• W4313472238 cites W2169678694 @default.
• W4313472238 cites W2171353131 @default.
• W4313472238 cites W2470165008 @default.
• W4313472238 cites W2791400386 @default.
• W4313472238 cites W2894970413 @default.
• W4313472238 cites W3028473642 @default.
• W4313472238 cites W3048560933 @default.
• W4313472238 cites W3107025025 @default.
• W4313472238 cites W3113001728 @default.
• W4313472238 cites W3123421077 @default.
• W4313472238 cites W3165644756 @default.
• W4313472238 cites W3167364663 @default.
• W4313472238 cites W3198660134 @default.
• W4313472238 cites W3207751428 @default.
• W4313472238 cites W4252439374 @default.
• W4313472238 doi "https://doi.org/10.3390/v15010124" @default.
• W4313472238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36680163" @default.
• W4313472238 hasPublicationYear "2022" @default.
• W4313472238 type Work @default.
• W4313472238 citedByCount "2" @default.
• W4313472238 countsByYear W43134722382023 @default.
• W4313472238 crossrefType "journal-article" @default.
• W4313472238 hasAuthorship W4313472238A5013871287 @default.
• W4313472238 hasAuthorship W4313472238A5016326721 @default.
• W4313472238 hasAuthorship W4313472238A5030520632 @default.
• W4313472238 hasAuthorship W4313472238A5035466026 @default.
• W4313472238 hasAuthorship W4313472238A5063205557 @default.
• W4313472238 hasAuthorship W4313472238A5084503488 @default.
• W4313472238 hasBestOaLocation W43134722381 @default.
• W4313472238 hasConcept C104317684 @default.
• W4313472238 hasConcept C140704245 @default.
• W4313472238 hasConcept C159047783 @default.
• W4313472238 hasConcept C181199279 @default.
• W4313472238 hasConcept C2522874641 @default.
• W4313472238 hasConcept C2776449523 @default.
• W4313472238 hasConcept C2778009244 @default.
• W4313472238 hasConcept C41258723 @default.
• W4313472238 hasConcept C55493867 @default.
• W4313472238 hasConcept C67705224 @default.
• W4313472238 hasConcept C82381507 @default.
• W4313472238 hasConcept C86803240 @default.
• W4313472238 hasConceptScore W4313472238C104317684 @default.
• W4313472238 hasConceptScore W4313472238C140704245 @default.
• W4313472238 hasConceptScore W4313472238C159047783 @default.
• W4313472238 hasConceptScore W4313472238C181199279 @default.
• W4313472238 hasConceptScore W4313472238C2522874641 @default.
• W4313472238 hasConceptScore W4313472238C2776449523 @default.
• W4313472238 hasConceptScore W4313472238C2778009244 @default.
• W4313472238 hasConceptScore W4313472238C41258723 @default.
• W4313472238 hasConceptScore W4313472238C55493867 @default.
• W4313472238 hasConceptScore W4313472238C67705224 @default.
• W4313472238 hasConceptScore W4313472238C82381507 @default.
• W4313472238 hasConceptScore W4313472238C86803240 @default.
• W4313472238 hasFunder F4320322817 @default.
• W4313472238 hasFunder F4320335038 @default.
• W4313472238 hasIssue "1" @default.
• W4313472238 hasLocation W43134722381 @default.
• W4313472238 hasLocation W43134722382 @default.
• W4313472238 hasLocation W43134722383 @default.
• W4313472238 hasOpenAccess W4313472238 @default.
• W4313472238 hasPrimaryLocation W43134722381 @default.
• W4313472238 hasRelatedWork W1243114843 @default.
• W4313472238 hasRelatedWork W1558257800 @default.

• next