Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313472283> ?p ?o ?g. }
- W4313472283 endingPage "233" @default.
- W4313472283 startingPage "233" @default.
- W4313472283 abstract "Triple-negative tumors are progressively delineating their existence over the extended spectrum of breast cancers, marked by intricate molecular heterogeneity, a low overall survival rate, and an unexplored therapeutic approach. Although the basal subtype transcends the group and contributes approximately 80% to triple-negative breast cancer (TNBC) cases, the exceptionally appearing mesenchymal and luminal androgen receptor (LAR) subtypes portray an unfathomable clinical course. LAR with a distinct generic profile frequently metastasizes to regional lymph nodes and bones. This subtype is minimally affected by chemotherapy and shows the lowest pathologic complete response. The androgen receptor is the only sex steroid receptor that plays a cardinal role in the progression of breast cancers and is typically overexpressed in LAR. The partial AR antagonist bicalutamide and the next-generation AR inhibitor enzalutamide are being assessed in standard protocols for the mitigation of TNBC. There arises an inevitable need to probe into the strategies that could neutralize these androgen receptors and alleviate the trajectory of concerning cancer. This paper thus focuses on reviewing literature that provides insights into the anti-androgenic elements against LAR typical TNBC that could pave the way for clinical advancements in this dynamic sphere of oncology." @default.
- W4313472283 created "2023-01-06" @default.
- W4313472283 creator A5003669043 @default.
- W4313472283 creator A5030595429 @default.
- W4313472283 creator A5044124687 @default.
- W4313472283 creator A5058201241 @default.
- W4313472283 creator A5058455782 @default.
- W4313472283 creator A5082658710 @default.
- W4313472283 date "2022-12-30" @default.
- W4313472283 modified "2023-10-10" @default.
- W4313472283 title "Anti-Androgenic Therapies Targeting the Luminal Androgen Receptor of a Typical Triple-Negative Breast Cancer" @default.
- W4313472283 cites W1864088128 @default.
- W4313472283 cites W1904684630 @default.
- W4313472283 cites W1990609319 @default.
- W4313472283 cites W2048264433 @default.
- W4313472283 cites W2063284702 @default.
- W4313472283 cites W2086519305 @default.
- W4313472283 cites W2088190208 @default.
- W4313472283 cites W2098804778 @default.
- W4313472283 cites W2114505219 @default.
- W4313472283 cites W2119401526 @default.
- W4313472283 cites W2134539328 @default.
- W4313472283 cites W2134928686 @default.
- W4313472283 cites W2139517025 @default.
- W4313472283 cites W2169594109 @default.
- W4313472283 cites W2186796676 @default.
- W4313472283 cites W2234203939 @default.
- W4313472283 cites W2280399394 @default.
- W4313472283 cites W2319293087 @default.
- W4313472283 cites W2403505910 @default.
- W4313472283 cites W2430731787 @default.
- W4313472283 cites W2505717779 @default.
- W4313472283 cites W2516519427 @default.
- W4313472283 cites W2523194272 @default.
- W4313472283 cites W2523391168 @default.
- W4313472283 cites W2548000951 @default.
- W4313472283 cites W2569617947 @default.
- W4313472283 cites W2588923250 @default.
- W4313472283 cites W2589522830 @default.
- W4313472283 cites W2591644378 @default.
- W4313472283 cites W2610242496 @default.
- W4313472283 cites W2663826054 @default.
- W4313472283 cites W2750544551 @default.
- W4313472283 cites W2755770908 @default.
- W4313472283 cites W2760827984 @default.
- W4313472283 cites W2766441357 @default.
- W4313472283 cites W2784775153 @default.
- W4313472283 cites W2801160548 @default.
- W4313472283 cites W2802528458 @default.
- W4313472283 cites W2806274529 @default.
- W4313472283 cites W2807966236 @default.
- W4313472283 cites W2887014156 @default.
- W4313472283 cites W2900870752 @default.
- W4313472283 cites W2903095656 @default.
- W4313472283 cites W2917000227 @default.
- W4313472283 cites W2923853552 @default.
- W4313472283 cites W2944220593 @default.
- W4313472283 cites W2946659976 @default.
- W4313472283 cites W2958370806 @default.
- W4313472283 cites W2971629853 @default.
- W4313472283 cites W2995209087 @default.
- W4313472283 cites W2999190661 @default.
- W4313472283 cites W2999201878 @default.
- W4313472283 cites W3009788319 @default.
- W4313472283 cites W3014646664 @default.
- W4313472283 cites W3018080545 @default.
- W4313472283 cites W3024764930 @default.
- W4313472283 cites W3033869790 @default.
- W4313472283 cites W3036170980 @default.
- W4313472283 cites W3087987460 @default.
- W4313472283 cites W3095318850 @default.
- W4313472283 cites W3096333099 @default.
- W4313472283 cites W3097546489 @default.
- W4313472283 cites W3105802462 @default.
- W4313472283 cites W3114814945 @default.
- W4313472283 cites W3120997246 @default.
- W4313472283 cites W3121204621 @default.
- W4313472283 cites W3128820310 @default.
- W4313472283 cites W3130335868 @default.
- W4313472283 cites W3136625942 @default.
- W4313472283 cites W3138947068 @default.
- W4313472283 cites W3140326616 @default.
- W4313472283 cites W3178468914 @default.
- W4313472283 cites W3187936920 @default.
- W4313472283 cites W3193347331 @default.
- W4313472283 cites W3213236073 @default.
- W4313472283 cites W4200191922 @default.
- W4313472283 cites W4205242376 @default.
- W4313472283 cites W4214500057 @default.
- W4313472283 cites W4214558836 @default.
- W4313472283 cites W4225277224 @default.
- W4313472283 cites W4286296204 @default.
- W4313472283 cites W4292415327 @default.
- W4313472283 cites W4293435090 @default.
- W4313472283 cites W4295973382 @default.
- W4313472283 cites W2517022125 @default.
- W4313472283 cites W4283029752 @default.
- W4313472283 doi "https://doi.org/10.3390/cancers15010233" @default.