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- W4313472551 endingPage "378" @default.
- W4313472551 startingPage "378" @default.
- W4313472551 abstract "Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis. In the current review, different chemical derivatives are explored which have been used as anti-melanogenic compounds. These are different chemical compounds naturally present in plants and semi-synthetic and synthetic compounds inspired by these natural products, such as kojic acid produced by several species of fungi; arbutin-a glycosylated hydroquinone extracted from the bearberry plant; vanillin-a phenolic aldehyde extracted from the vanilla bean, etc. After enzyme inhibition screening, various chemical compounds showed different therapeutic effects as tyrosinase inhibitors with different values of the inhibition constant and IC50. We show how appropriately designed scaffolds inspired by the structures of natural compounds are used to develop novel synthetic inhibitors. We review the results of numerous studies, which could lead to the development of effective anti-tyrosinase agents with increased efficiency and safety in the near future, with many applications in the food, pharmaceutical and cosmetics industries." @default.
- W4313472551 created "2023-01-06" @default.
- W4313472551 creator A5060140532 @default.
- W4313472551 creator A5076295992 @default.
- W4313472551 creator A5086880109 @default.
- W4313472551 date "2023-01-02" @default.
- W4313472551 modified "2023-10-10" @default.
- W4313472551 title "Tyrosinase Inhibitors Naturally Present in Plants and Synthetic Modifications of These Natural Products as Anti-Melanogenic Agents: A Review" @default.
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