Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313472749> ?p ?o ?g. }
- W4313472749 endingPage "101" @default.
- W4313472749 startingPage "101" @default.
- W4313472749 abstract "Prostate cancer is a common form of cancer in men, and androgen-deprivation therapy (ADT) is often used as a first-line treatment. However, some patients develop resistance to ADT, and their disease is called castration-resistant prostate cancer (CRPC). Identifying potential therapeutic targets for this aggressive subtype of prostate cancer is crucial. In this study, we show that statins can selectively inhibit the growth of these CRPC tumors that have lost their androgen receptor (AR) and have overexpressed the RNA-binding protein QKI. We found that the repression of microRNA-200 by QKI overexpression promotes the rise of AR-low mesenchymal-like CRPC cells. Using in silico drug/gene perturbation combined screening, we discovered that QKI-overexpressing cancer cells are selectively vulnerable to CDC42-PAK7 inhibition by statins. We also confirmed that PAK7 overexpression is present in prostate cancer that coexists with hyperlipidemia. Our results demonstrate a previously unseen mechanism of action for statins in these QKI-expressing AR-lost CRPCs. This may explain the clinical benefits of the drug and support the development of a biology-driven drug-repurposing clinical trial. This is an important finding that could help improve treatment options for patients with this aggressive form of prostate cancer." @default.
- W4313472749 created "2023-01-06" @default.
- W4313472749 creator A5003725562 @default.
- W4313472749 creator A5016101715 @default.
- W4313472749 creator A5045730291 @default.
- W4313472749 creator A5054207755 @default.
- W4313472749 creator A5071545432 @default.
- W4313472749 creator A5090913495 @default.
- W4313472749 date "2022-12-30" @default.
- W4313472749 modified "2023-10-14" @default.
- W4313472749 title "Androgen-Independent Prostate Cancer Is Sensitive to CDC42-PAK7 Kinase Inhibition" @default.
- W4313472749 cites W1578291413 @default.
- W4313472749 cites W1963691340 @default.
- W4313472749 cites W1976324983 @default.
- W4313472749 cites W1977251381 @default.
- W4313472749 cites W2002546470 @default.
- W4313472749 cites W2005958584 @default.
- W4313472749 cites W2006169630 @default.
- W4313472749 cites W2010688739 @default.
- W4313472749 cites W2012619882 @default.
- W4313472749 cites W2016034838 @default.
- W4313472749 cites W2017139179 @default.
- W4313472749 cites W2030819637 @default.
- W4313472749 cites W2056643845 @default.
- W4313472749 cites W2069576182 @default.
- W4313472749 cites W2082765327 @default.
- W4313472749 cites W2106647992 @default.
- W4313472749 cites W2107960969 @default.
- W4313472749 cites W2110014936 @default.
- W4313472749 cites W2110534364 @default.
- W4313472749 cites W2124033164 @default.
- W4313472749 cites W2125120607 @default.
- W4313472749 cites W2125146007 @default.
- W4313472749 cites W2127862779 @default.
- W4313472749 cites W2130979840 @default.
- W4313472749 cites W2134629862 @default.
- W4313472749 cites W2140257324 @default.
- W4313472749 cites W2145387574 @default.
- W4313472749 cites W2152883907 @default.
- W4313472749 cites W2155131748 @default.
- W4313472749 cites W2158671081 @default.
- W4313472749 cites W2159220884 @default.
- W4313472749 cites W2165616810 @default.
- W4313472749 cites W2166918329 @default.
- W4313472749 cites W2171296186 @default.
- W4313472749 cites W2175970000 @default.
- W4313472749 cites W2220553089 @default.
- W4313472749 cites W2262087934 @default.
- W4313472749 cites W2302291515 @default.
- W4313472749 cites W2311347322 @default.
- W4313472749 cites W2337780126 @default.
- W4313472749 cites W2571250257 @default.
- W4313472749 cites W2587831406 @default.
- W4313472749 cites W2598884790 @default.
- W4313472749 cites W2613716330 @default.
- W4313472749 cites W2727828415 @default.
- W4313472749 cites W2741508285 @default.
- W4313472749 cites W2762381618 @default.
- W4313472749 cites W2778262854 @default.
- W4313472749 cites W2783366082 @default.
- W4313472749 cites W2792086148 @default.
- W4313472749 cites W2798231099 @default.
- W4313472749 cites W2804407464 @default.
- W4313472749 cites W2807280571 @default.
- W4313472749 cites W2913767564 @default.
- W4313472749 cites W3003173606 @default.
- W4313472749 cites W3160706451 @default.
- W4313472749 cites W3217631836 @default.
- W4313472749 cites W4223448876 @default.
- W4313472749 cites W4237882759 @default.
- W4313472749 cites W4286293777 @default.
- W4313472749 doi "https://doi.org/10.3390/biomedicines11010101" @default.
- W4313472749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672609" @default.
- W4313472749 hasPublicationYear "2022" @default.
- W4313472749 type Work @default.
- W4313472749 citedByCount "2" @default.
- W4313472749 countsByYear W43134727492023 @default.
- W4313472749 crossrefType "journal-article" @default.
- W4313472749 hasAuthorship W4313472749A5003725562 @default.
- W4313472749 hasAuthorship W4313472749A5016101715 @default.
- W4313472749 hasAuthorship W4313472749A5045730291 @default.
- W4313472749 hasAuthorship W4313472749A5054207755 @default.
- W4313472749 hasAuthorship W4313472749A5071545432 @default.
- W4313472749 hasAuthorship W4313472749A5090913495 @default.
- W4313472749 hasBestOaLocation W43134727491 @default.
- W4313472749 hasConcept C121608353 @default.
- W4313472749 hasConcept C126322002 @default.
- W4313472749 hasConcept C142669718 @default.
- W4313472749 hasConcept C1491633281 @default.
- W4313472749 hasConcept C184235292 @default.
- W4313472749 hasConcept C20563397 @default.
- W4313472749 hasConcept C2777899217 @default.
- W4313472749 hasConcept C2779684405 @default.
- W4313472749 hasConcept C2780040266 @default.
- W4313472749 hasConcept C2780192828 @default.
- W4313472749 hasConcept C502942594 @default.
- W4313472749 hasConcept C54355233 @default.
- W4313472749 hasConcept C61367390 @default.