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- W4313473064 endingPage "86" @default.
- W4313473064 startingPage "86" @default.
- W4313473064 abstract "Background: Tuberculosis (TB) is currently the second greatest killer worldwide and is caused by a single infectious agent. Since Bacillus Calmette–Guérin (BCG) is the only vaccine currently in use against TB, studies addressing the protective role of BCG in the context of inducible surface biomarkers are urgently required for TB control. Methods: In this study, groups of HIV-negative adult healthy donors (HD; n = 22) and neonate samples (UCB; n = 48) were voluntarily enrolled. The BCG Moreau strain was used for the in vitro mononuclear cell infections. Subsequently, phenotyping tools were used for surface biomarker detection. Monocytes were assayed for TLR4, B7-1, Dectin-1, EP2, and TIM-3 expression levels. Results: At 48 h, the BCG Moreau induced the highest TLR4, B7-1, and Dectin-1 levels in the HD group only (p-value < 0.05). TIM-3 expression failed to be modulated after BCG infection. At 72 h, BCG Moreau equally induced the highest EP2 levels in the HD group (p-value < 0.005), and higher levels were also found in HD when compared with the UCB group (p-value < 0.05). Conclusions: This study uncovers critical roles for biomarkers after the instruction of host monocyte activation patterns. Understanding the regulation of human innate immune responses is critical for vaccine development and for treating infectious diseases." @default.
- W4313473064 created "2023-01-06" @default.
- W4313473064 creator A5023922727 @default.
- W4313473064 creator A5025865363 @default.
- W4313473064 creator A5041751783 @default.
- W4313473064 creator A5066037763 @default.
- W4313473064 creator A5067494679 @default.
- W4313473064 creator A5077706874 @default.
- W4313473064 creator A5086243217 @default.
- W4313473064 date "2022-12-30" @default.
- W4313473064 modified "2023-10-16" @default.
- W4313473064 title "The BCG Moreau Vaccine Upregulates In Vitro the Expression of TLR4, B7-1, Dectin-1 and EP2 on Human Monocytes" @default.
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- W4313473064 doi "https://doi.org/10.3390/vaccines11010086" @default.
- W4313473064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36679931" @default.
- W4313473064 hasPublicationYear "2022" @default.
- W4313473064 type Work @default.