Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313473071> ?p ?o ?g. }
- W4313473071 endingPage "67" @default.
- W4313473071 startingPage "67" @default.
- W4313473071 abstract "Background: Lomentospora prolificans, a rare, highly virulent filamentous fungus with high rates of intrinsic resistance to antifungals, has been associated with different types of infections in immunocompromised as well as immunocompetent individuals. Objective: To systematically address all relevant evidence regarding L. prolificans disseminated infections in the literature. Methods: We searched Medline via PubMed and Scopus databases through July 2022. We performed a qualitative synthesis of published articles reporting disseminated infections from L. prolificans in humans. Results: A total of 87 studies describing 142 cases were included in our systematic review. The pathogen was most frequently reported in disseminated infections in Spain (n = 47), Australia (n = 33), the USA (n = 21), and Germany (n = 10). Among 142 reported cases, 48.5% were males. Underlying conditions identified for the majority of patients included malignancy (72.5%), hemopoietic stem cell transplantation (23.2%), solid organ transplantation (16%), and AIDS (2%). Lungs, central nervous system, skin, eyes, heart and bones/joints were the most commonly affected organs. Neutropenia was recorded in 52% of patients. The mortality rate was as high as 87.3%. Conclusions: To the best of our knowledge, this is the first systematic review conducted on disseminated infections due to this rare microorganism. Physicians should be aware that L. prolificans can cause a diversity of infections with high mortality and primarily affects immunocompromised and neutropenic patients." @default.
- W4313473071 created "2023-01-06" @default.
- W4313473071 creator A5002384640 @default.
- W4313473071 creator A5005610081 @default.
- W4313473071 creator A5020696225 @default.
- W4313473071 creator A5036679229 @default.
- W4313473071 creator A5088348112 @default.
- W4313473071 date "2022-12-31" @default.
- W4313473071 modified "2023-10-14" @default.
- W4313473071 title "Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases" @default.
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