FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313473143> ?p ?o ?g. }

• W4313473143 endingPage "337" @default.
• W4313473143 startingPage "337" @default.
• W4313473143 abstract "Biliary atresia (BA) is a progressive pediatric inflammatory disease of the liver that leads to cirrhosis and necessitates liver transplantation. The rapid progression from liver injury to liver failure in children with BA suggests that factors specific to the perinatal hepatic environment are important for disease propagation. Hematopoietic stem and progenitor cells (HSPCs) reside in the fetal liver and are known to serve as central hubs of inflammation. We hypothesized that HSPCs are critical for the propagation of perinatal liver injury (PLI).Newborn BALB/c mice were injected with rhesus rotavirus (RRV) to induce PLI or with PBS as control. Livers were compared using histology and flow cytometry. To determine the effects of HSPCs on PLI, RRV-infected neonatal mice were administered anti-CD47 and anti-CD117 to deplete HSPCs.PLI significantly increased the number of common myeloid progenitors and the number of CD34+ hematopoietic progenitors. Elimination of HSPCs through antibody-mediated myeloablation rescued animals from PLI and significantly increased survival (RRV+isotype control 36.4% vs. RRV+myeloablation 77.8%, Chi-test = 0.003).HSPCs expand as a result of RRV infection and propagate PLI. Targeting of HSPCs may be useful in preventing and treating neonatal inflammatory diseases of the liver such as BA." @default.
• W4313473143 created "2023-01-06" @default.
• W4313473143 creator A5024112006 @default.
• W4313473143 creator A5028380632 @default.
• W4313473143 creator A5046469157 @default.
• W4313473143 creator A5052069924 @default.
• W4313473143 creator A5062978953 @default.
• W4313473143 creator A5064136067 @default.
• W4313473143 creator A5066990834 @default.
• W4313473143 date "2023-01-01" @default.
• W4313473143 modified "2023-09-26" @default.
• W4313473143 title "Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice" @default.
• W4313473143 cites W1521262132 @default.
• W4313473143 cites W1965482656 @default.
• W4313473143 cites W1974773677 @default.
• W4313473143 cites W1989721541 @default.
• W4313473143 cites W2005167736 @default.
• W4313473143 cites W2022553425 @default.
• W4313473143 cites W2024366740 @default.
• W4313473143 cites W2038920846 @default.
• W4313473143 cites W2049781837 @default.
• W4313473143 cites W2061994584 @default.
• W4313473143 cites W2090510507 @default.
• W4313473143 cites W2205886515 @default.
• W4313473143 cites W2500588363 @default.
• W4313473143 cites W2783469772 @default.
• W4313473143 cites W2808785156 @default.
• W4313473143 cites W2886524403 @default.
• W4313473143 cites W2908317404 @default.
• W4313473143 cites W2913429766 @default.
• W4313473143 cites W2917608643 @default.
• W4313473143 cites W2937065926 @default.
• W4313473143 cites W2952481429 @default.
• W4313473143 cites W2952520385 @default.
• W4313473143 cites W3006543472 @default.
• W4313473143 cites W3009920944 @default.
• W4313473143 cites W3018907963 @default.
• W4313473143 cites W3044185459 @default.
• W4313473143 cites W3112419967 @default.
• W4313473143 cites W3154888085 @default.
• W4313473143 cites W3156224998 @default.
• W4313473143 cites W4200122181 @default.
• W4313473143 cites W4225141679 @default.
• W4313473143 doi "https://doi.org/10.3390/jcm12010337" @default.
• W4313473143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36615137" @default.
• W4313473143 hasPublicationYear "2023" @default.
• W4313473143 type Work @default.
• W4313473143 citedByCount "1" @default.
• W4313473143 countsByYear W43134731432023 @default.
• W4313473143 crossrefType "journal-article" @default.
• W4313473143 hasAuthorship W4313473143A5024112006 @default.
• W4313473143 hasAuthorship W4313473143A5028380632 @default.
• W4313473143 hasAuthorship W4313473143A5046469157 @default.
• W4313473143 hasAuthorship W4313473143A5052069924 @default.
• W4313473143 hasAuthorship W4313473143A5062978953 @default.
• W4313473143 hasAuthorship W4313473143A5064136067 @default.
• W4313473143 hasAuthorship W4313473143A5066990834 @default.
• W4313473143 hasBestOaLocation W43134731431 @default.
• W4313473143 hasConcept C10205521 @default.
• W4313473143 hasConcept C109159458 @default.
• W4313473143 hasConcept C126322002 @default.
• W4313473143 hasConcept C16685009 @default.
• W4313473143 hasConcept C201750760 @default.
• W4313473143 hasConcept C203014093 @default.
• W4313473143 hasConcept C2776637226 @default.
• W4313473143 hasConcept C2777075537 @default.
• W4313473143 hasConcept C2777214474 @default.
• W4313473143 hasConcept C2779243279 @default.
• W4313473143 hasConcept C2779282312 @default.
• W4313473143 hasConcept C2779609443 @default.
• W4313473143 hasConcept C28328180 @default.
• W4313473143 hasConcept C2911091166 @default.
• W4313473143 hasConcept C71924100 @default.
• W4313473143 hasConcept C86803240 @default.
• W4313473143 hasConcept C95444343 @default.
• W4313473143 hasConceptScore W4313473143C10205521 @default.
• W4313473143 hasConceptScore W4313473143C109159458 @default.
• W4313473143 hasConceptScore W4313473143C126322002 @default.
• W4313473143 hasConceptScore W4313473143C16685009 @default.
• W4313473143 hasConceptScore W4313473143C201750760 @default.
• W4313473143 hasConceptScore W4313473143C203014093 @default.
• W4313473143 hasConceptScore W4313473143C2776637226 @default.
• W4313473143 hasConceptScore W4313473143C2777075537 @default.
• W4313473143 hasConceptScore W4313473143C2777214474 @default.
• W4313473143 hasConceptScore W4313473143C2779243279 @default.
• W4313473143 hasConceptScore W4313473143C2779282312 @default.
• W4313473143 hasConceptScore W4313473143C2779609443 @default.
• W4313473143 hasConceptScore W4313473143C28328180 @default.
• W4313473143 hasConceptScore W4313473143C2911091166 @default.
• W4313473143 hasConceptScore W4313473143C71924100 @default.
• W4313473143 hasConceptScore W4313473143C86803240 @default.
• W4313473143 hasConceptScore W4313473143C95444343 @default.
• W4313473143 hasFunder F4320337357 @default.
• W4313473143 hasIssue "1" @default.
• W4313473143 hasLocation W43134731431 @default.
• W4313473143 hasLocation W43134731432 @default.
• W4313473143 hasLocation W43134731433 @default.
• W4313473143 hasLocation W43134731434 @default.

• next