FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313473192> ?p ?o ?g. }

• W4313473192 endingPage "771" @default.
• W4313473192 startingPage "771" @default.
• W4313473192 abstract "To elucidate the currently unknown molecular mechanisms responsible for the aberrant expression of recoverin (Rec) within cancerous cells, we examined two-dimensional (2D) and three-dimensional (3D) cultures of Rec-negative lung adenocarcinoma A549 cells which had been transfected with a plasmid containing human recoverin cDNA (A549 Rec) or an empty plasmid as a mock control (A549 MOCK). Using these cells, we measured cytotoxicity by several anti-tumor agents (2D), cellular metabolism including mitochondrial and glycolytic functions by a Seahorse bio-analyzer (2D), the physical properties, size and stiffness of the 3D spheroids, trypsin sensitivities (2D and 3D), and RNA sequencing analysis (2D). Compared with the A549 MOCK, the A549 Rec cells showed (1) more sensitivity toward anti-tumor agents (2D) and a 0.25% solution of trypsin (3D); (2) a metabolic shift from glycolysis to oxidative phosphorylation; and (3) the formation of larger and stiffer 3D spheroids. RNA sequencing analysis and bioinformatic analyses of the differentially expressed genes (DEGs) using Gene Ontology (GO) enrichment analysis suggested that aberrantly expressed Rec is most likely associated with several canonical pathways including G-protein-coupled receptor (GPCR)-mediated signaling and signaling by the cAMP response element binding protein (CREB). The findings reported here indicate that the aberrantly expressed Rec-induced modulation of the cell viability and drug sensitivity may be GPCR mediated." @default.
• W4313473192 created "2023-01-06" @default.
• W4313473192 creator A5014326078 @default.
• W4313473192 creator A5017804701 @default.
• W4313473192 creator A5039100229 @default.
• W4313473192 creator A5061939029 @default.
• W4313473192 creator A5062469551 @default.
• W4313473192 creator A5072637751 @default.
• W4313473192 creator A5075406091 @default.
• W4313473192 creator A5085673410 @default.
• W4313473192 creator A5089380224 @default.
• W4313473192 date "2023-01-01" @default.
• W4313473192 modified "2023-10-18" @default.
• W4313473192 title "G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells" @default.
• W4313473192 cites W1533937831 @default.
• W4313473192 cites W1562084799 @default.
• W4313473192 cites W1573108780 @default.
• W4313473192 cites W1583630376 @default.
• W4313473192 cites W1665694480 @default.
• W4313473192 cites W1799705133 @default.
• W4313473192 cites W1846653936 @default.
• W4313473192 cites W1964195895 @default.
• W4313473192 cites W1967814790 @default.
• W4313473192 cites W1975901029 @default.
• W4313473192 cites W1978279440 @default.
• W4313473192 cites W1981254976 @default.
• W4313473192 cites W1988312770 @default.
• W4313473192 cites W1996895789 @default.
• W4313473192 cites W2008828780 @default.
• W4313473192 cites W2018735131 @default.
• W4313473192 cites W2032597695 @default.
• W4313473192 cites W2036683586 @default.
• W4313473192 cites W2043949734 @default.
• W4313473192 cites W2057724921 @default.
• W4313473192 cites W2060320925 @default.
• W4313473192 cites W2060526583 @default.
• W4313473192 cites W2060839103 @default.
• W4313473192 cites W2071827667 @default.
• W4313473192 cites W2073231719 @default.
• W4313473192 cites W2075796682 @default.
• W4313473192 cites W2081617200 @default.
• W4313473192 cites W2083358105 @default.
• W4313473192 cites W2084947365 @default.
• W4313473192 cites W2086703017 @default.
• W4313473192 cites W2087900138 @default.
• W4313473192 cites W2095794663 @default.
• W4313473192 cites W2101100140 @default.
• W4313473192 cites W2102278945 @default.
• W4313473192 cites W2115201271 @default.
• W4313473192 cites W2116309149 @default.
• W4313473192 cites W2162143298 @default.
• W4313473192 cites W2167179773 @default.
• W4313473192 cites W2213347440 @default.
• W4313473192 cites W2315576591 @default.
• W4313473192 cites W2416143757 @default.
• W4313473192 cites W2591635448 @default.
• W4313473192 cites W2592456314 @default.
• W4313473192 cites W2614496215 @default.
• W4313473192 cites W2802987970 @default.
• W4313473192 cites W2899444928 @default.
• W4313473192 cites W2986790007 @default.
• W4313473192 cites W3025467888 @default.
• W4313473192 cites W3033833994 @default.
• W4313473192 cites W3089721064 @default.
• W4313473192 cites W3144484103 @default.
• W4313473192 cites W3202983394 @default.
• W4313473192 cites W3217594228 @default.
• W4313473192 cites W4205928324 @default.
• W4313473192 cites W4224257329 @default.
• W4313473192 doi "https://doi.org/10.3390/ijms24010771" @default.
• W4313473192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614215" @default.
• W4313473192 hasPublicationYear "2023" @default.
• W4313473192 type Work @default.
• W4313473192 citedByCount "3" @default.
• W4313473192 countsByYear W43134731922023 @default.
• W4313473192 crossrefType "journal-article" @default.
• W4313473192 hasAuthorship W4313473192A5014326078 @default.
• W4313473192 hasAuthorship W4313473192A5017804701 @default.
• W4313473192 hasAuthorship W4313473192A5039100229 @default.
• W4313473192 hasAuthorship W4313473192A5061939029 @default.
• W4313473192 hasAuthorship W4313473192A5062469551 @default.
• W4313473192 hasAuthorship W4313473192A5072637751 @default.
• W4313473192 hasAuthorship W4313473192A5075406091 @default.
• W4313473192 hasAuthorship W4313473192A5085673410 @default.
• W4313473192 hasAuthorship W4313473192A5089380224 @default.
• W4313473192 hasBestOaLocation W43134731921 @default.
• W4313473192 hasConcept C1491633281 @default.
• W4313473192 hasConcept C153911025 @default.
• W4313473192 hasConcept C170493617 @default.
• W4313473192 hasConcept C202033177 @default.
• W4313473192 hasConcept C2780827179 @default.
• W4313473192 hasConcept C2781139644 @default.
• W4313473192 hasConcept C55493867 @default.
• W4313473192 hasConcept C62478195 @default.
• W4313473192 hasConcept C81729549 @default.
• W4313473192 hasConcept C86803240 @default.
• W4313473192 hasConcept C95444343 @default.
• W4313473192 hasConceptScore W4313473192C1491633281 @default.

• next