Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313473365> ?p ?o ?g. }
- W4313473365 endingPage "231" @default.
- W4313473365 startingPage "231" @default.
- W4313473365 abstract "In patients with advanced ovarian cancer (AOC) receiving neoadjuvant chemotherapy (NAC), predicting the feasibility of complete interval cytoreductive surgery (ICRS) is helpful and may avoid unnecessary laparotomy. A joint model (JM) is a dynamic individual predictive model. The aim of this study was to develop a predictive JM combining CA-125 kinetics during NAC with patients' and clinical factors to predict resectability after NAC in patients with AOC. A retrospective study included 77 patients with AOC treated with NAC. A linear mixed effect (LME) sub-model was used to describe the evolution of CA-125 during NAC considering factors influencing the biomarker levels. A Cox sub-model screened the covariates associated with resectability. The JM combined the LME sub-model with the Cox sub-model. Using the LME sub-model, we observed that CA-125 levels were influenced by the number of NAC cycles and the performance of paracentesis. In the Cox sub-model, complete resectability was associated with Performance Status (HR = 0.57, [0.34-0.95], p = 0.03) and the presence of peritoneal carcinomatosis in the epigastric region (HR = 0.39, [0.19-0.80], p = 0.01). The JM accuracy to predict complete ICRS was 88% [82-100] with a predictive error of 2.24% [0-2.32]. Using a JM of a longitudinal CA-125 level during NAC could be a reliable predictor of complete ICRS." @default.
- W4313473365 created "2023-01-06" @default.
- W4313473365 creator A5003301011 @default.
- W4313473365 creator A5030696434 @default.
- W4313473365 creator A5050585830 @default.
- W4313473365 creator A5066488761 @default.
- W4313473365 creator A5067683186 @default.
- W4313473365 creator A5068737731 @default.
- W4313473365 creator A5071402891 @default.
- W4313473365 creator A5077000250 @default.
- W4313473365 date "2022-12-30" @default.
- W4313473365 modified "2023-10-05" @default.
- W4313473365 title "Dynamic Prediction of Resectability for Patients with Advanced Ovarian Cancer Undergoing Neo-Adjuvant Chemotherapy: Application of Joint Model for Longitudinal CA-125 Levels" @default.
- W4313473365 cites W12278151 @default.
- W4313473365 cites W17791541 @default.
- W4313473365 cites W1832181941 @default.
- W4313473365 cites W1969121873 @default.
- W4313473365 cites W1983212153 @default.
- W4313473365 cites W1990533787 @default.
- W4313473365 cites W1993505171 @default.
- W4313473365 cites W1993928534 @default.
- W4313473365 cites W2000753604 @default.
- W4313473365 cites W2008276565 @default.
- W4313473365 cites W2018100760 @default.
- W4313473365 cites W2019279887 @default.
- W4313473365 cites W2024297717 @default.
- W4313473365 cites W2031444792 @default.
- W4313473365 cites W2032758468 @default.
- W4313473365 cites W2043558235 @default.
- W4313473365 cites W2059558296 @default.
- W4313473365 cites W2060465654 @default.
- W4313473365 cites W2060922610 @default.
- W4313473365 cites W2061074110 @default.
- W4313473365 cites W2065594845 @default.
- W4313473365 cites W2073945103 @default.
- W4313473365 cites W2075768271 @default.
- W4313473365 cites W2080057426 @default.
- W4313473365 cites W2093716230 @default.
- W4313473365 cites W2114048637 @default.
- W4313473365 cites W2130806638 @default.
- W4313473365 cites W2133170779 @default.
- W4313473365 cites W2134481878 @default.
- W4313473365 cites W2145217466 @default.
- W4313473365 cites W2154074334 @default.
- W4313473365 cites W2168803496 @default.
- W4313473365 cites W2179214054 @default.
- W4313473365 cites W2183370948 @default.
- W4313473365 cites W2520768140 @default.
- W4313473365 cites W2520806078 @default.
- W4313473365 cites W2563873551 @default.
- W4313473365 cites W2767760956 @default.
- W4313473365 cites W2802746649 @default.
- W4313473365 cites W2981980002 @default.
- W4313473365 cites W2991879135 @default.
- W4313473365 cites W3012975398 @default.
- W4313473365 cites W4249977521 @default.
- W4313473365 doi "https://doi.org/10.3390/cancers15010231" @default.
- W4313473365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36612234" @default.
- W4313473365 hasPublicationYear "2022" @default.
- W4313473365 type Work @default.
- W4313473365 citedByCount "0" @default.
- W4313473365 crossrefType "journal-article" @default.
- W4313473365 hasAuthorship W4313473365A5003301011 @default.
- W4313473365 hasAuthorship W4313473365A5030696434 @default.
- W4313473365 hasAuthorship W4313473365A5050585830 @default.
- W4313473365 hasAuthorship W4313473365A5066488761 @default.
- W4313473365 hasAuthorship W4313473365A5067683186 @default.
- W4313473365 hasAuthorship W4313473365A5068737731 @default.
- W4313473365 hasAuthorship W4313473365A5071402891 @default.
- W4313473365 hasAuthorship W4313473365A5077000250 @default.
- W4313473365 hasBestOaLocation W43134733651 @default.
- W4313473365 hasConcept C121608353 @default.
- W4313473365 hasConcept C126322002 @default.
- W4313473365 hasConcept C141071460 @default.
- W4313473365 hasConcept C143998085 @default.
- W4313473365 hasConcept C185592680 @default.
- W4313473365 hasConcept C2776694085 @default.
- W4313473365 hasConcept C2780427987 @default.
- W4313473365 hasConcept C2780778865 @default.
- W4313473365 hasConcept C2781197716 @default.
- W4313473365 hasConcept C3019719930 @default.
- W4313473365 hasConcept C50382708 @default.
- W4313473365 hasConcept C55493867 @default.
- W4313473365 hasConcept C71924100 @default.
- W4313473365 hasConceptScore W4313473365C121608353 @default.
- W4313473365 hasConceptScore W4313473365C126322002 @default.
- W4313473365 hasConceptScore W4313473365C141071460 @default.
- W4313473365 hasConceptScore W4313473365C143998085 @default.
- W4313473365 hasConceptScore W4313473365C185592680 @default.
- W4313473365 hasConceptScore W4313473365C2776694085 @default.
- W4313473365 hasConceptScore W4313473365C2780427987 @default.
- W4313473365 hasConceptScore W4313473365C2780778865 @default.
- W4313473365 hasConceptScore W4313473365C2781197716 @default.
- W4313473365 hasConceptScore W4313473365C3019719930 @default.
- W4313473365 hasConceptScore W4313473365C50382708 @default.
- W4313473365 hasConceptScore W4313473365C55493867 @default.
- W4313473365 hasConceptScore W4313473365C71924100 @default.
- W4313473365 hasIssue "1" @default.