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• W4313474958 abstract "Aim. To determine the composition and properties of the gut microbiota in HIV-infected patients with pulmonary tuberculosis. Materials and Methods. We studied 92 faecal samples from patients with pulmonary tuberculosis (n = 46) and patients with combined pulmonary tuberculosis and HIV infection (n = 46), with the following examination of the appearance, cultural properties, and biochemical profile of the bacteria. The constancy of microbial taxa was determined using Dazho-Odum indicator. Microorganisms were classified as constant at C > 50%, as complementary at 25% < C < 50% and as occasional at C < 25%. Results. Gut microbiota of patients with multidrug-resistant tuberculosis was consistently represented by Bifidobacterium spp. , Lactobacillus spp. , Enterococcus spp. , Escherichia spp. , Staphylococcus spp. , and Candida regardless of their HIV status. Species composition and prevalence of virulence factors in Staphylococcus spp. and fungi isolated from patients with multidrug-resistant tuberculosis also did not depend on HIV status. Complementary microorganisms were represented exclusively by Clostridium spp ., while random microbiota was represented by 6 genera ( Enterobacter spp., Citrobacter spp., Salmonella spp., Klebsiella spp., Proteus spp., and Pseudomonas spp. ) belonging to the Proteobacteria phylum. Conclusion. Similar composition of gut microbiota in HIV-positive and HIV-negative patients with multidrug-resistant tuberculosis indicates common mechanisms of intestinal dysbiosis and a uniform approach for its correction." @default.
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• W4313474958 date "2022-12-29" @default.
• W4313474958 modified "2023-10-16" @default.
• W4313474958 title "Gut microbiota of HIV-infected patients with multidrug-resistant tuberculosis" @default.
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• W4313474958 doi "https://doi.org/10.23946/2500-0764-2022-7-4-83-90" @default.
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