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- W4313475859 abstract "This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the most abundant in the heart. Sodium channel blockers have historically been called class I antiarrhythmics. Among the compounds of this type, a biaromatic structure mainly have the Nav1.5 late current blockers belonging to the Id subclass of antiarrhythmic drugs. Leader molecules from this subgroup, such as ranolazine, GS-458967, and F15845, reduce action potential recovery time and suppress trigger activity induced by early post-depolarization. They are effective for the treatment of stable angina and ventricular tachycardia." @default.
- W4313475859 created "2023-01-06" @default.
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- W4313475859 date "2022-12-20" @default.
- W4313475859 modified "2023-10-18" @default.
- W4313475859 title "Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers" @default.
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- W4313475859 doi "https://doi.org/10.37489/2587-7836-2022-3-3-9" @default.
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