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• W4313476111 abstract "Aim. To investigate the associations of idiotypic IgA antibodies against benzo[a]pyrene, estradiol and progesterone (IgA 1 -Bp, IgA1 -E2, and IgA 1 - Pg) with the corresponding anti-idiotypic IgG antibodies to estradiol and progesterone (IgG 2 -E2 and IgG 2 -Pg) and with gene polymorphisms of CYP1A1, CYP1A2, CYP1B1, CYP17A1, CYP19A1, GSTM1, GSTT1, and GSTP1 in patients with stage 1 breast cancer. Materials and Methods . Idiotypic and anti-idiotypic antibodies in the serum of 240 healthy women and 505 patients with stage 1 breast cancer were measured by enzyme-linked immunosorbent assay. Prevalence of CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP1B1 (rs1056836), CYP19A1 (rs2470152), GSTM1(del), GSTT1(del), and GSTP1 (rs1695) polymorphisms in 530 healthy women and 694 patients with stage 1 breast cancer were determined by real-time polymerase chain reaction. Result s. Low personal IgA 1 -Bp/IgA 1 -Pg < 1 and IgA 1 -E2/IgA 1 -Pg < 1 ratios in combination with low IgG 2 -E2 ≤ 4 and high IgG 2 -Pg > 2 levels were found in 20.6% of healthy women and in 4.5% of breast cancer patients (p < 0.0001; OR = 0.2). Low IgA 1 -Bp/IgA1 -Pg and high IgA 1 -E2/IgA 1 -Pg ratios in combination with low IgG 2 -E2 and high IgG 2 - Pg levels were revealed in 7.4% of healthy women and 2.8% of breast cancer patients (p = 0.009; OR = 0.4). These two variants were integrated and marked as protective immunological phenotype. High IgA 1 - Bp/IgA 1 -Pg and high IgA 1 -E2/IgA 1 -Pg ratios combined with high IgG 2 -Pg and high or low IgG 2 -E2 levels were found in 17.2% of healthy women and27.2% of breast cancer patients (p = 0.006; OR = 1.8) and in 6.4% of healthy women and in 18.3% of breast cancer patients (p < 0.0001; OR = 3.3), correspondingly. These two variants were integrated and marked as pro-carcinogenic immunological phenotype. These associations were found only with estrogen receptor-positive (ER+) breast cancer. GSTP1 (rs1695) gene polymorphism was associated exclusively with estrogen receptor-negative (ER-) breast cancer (p = 0.004; OR = 1.56). No interrelations be tween immunological phenotypes and studied polymorphisms of CYP and GST genes have been found. Conclusion . Pro-carcinogenic immunological phenotype and rs1695 gene polymorphism within the GSTP1 gene were independent predictors of ER+ and ER- breast cancer correspondingly." @default.
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• W4313476111 date "2022-12-29" @default.
• W4313476111 modified "2023-10-18" @default.
• W4313476111 title "Immunological and genetic predictors of breast cancer" @default.
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• W4313476111 doi "https://doi.org/10.23946/2500-0764-2022-7-4-51-62" @default.
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