Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313477007> ?p ?o ?g. }
- W4313477007 abstract "A growing body of preclinical studies report that preconceptional experiences can have a profound and long-lasting impact on adult offspring behavior and physiology. However, less is known about paternal drug exposure and its effects on reward sensitivity in the next generation.Adult male rats self-administered morphine for 65 days; controls received saline. Sires were bred to drug-naïve dams to produce first-generation (F1) offspring. Morphine, cocaine, and nicotine self-administration were measured in adult F1 progeny. Molecular correlates of addiction-like behaviors were measured in reward-related brain regions of drug naïve F1 offspring.Male, but not female offspring produced by morphine-exposed sires exhibited dose-dependent increased morphine self-administration and increased motivation to earn morphine infusions under a progressive ratio schedule of reinforcement. This phenotype was drug-specific as self-administration of cocaine, nicotine, and sucrose were not altered by paternal morphine history. The male offspring of morphine-exposed sires also had increased expression of mu-opioid receptors in the ventral tegmental area but not in the nucleus accumbens.Paternal morphine exposure increased morphine addiction-like behavioral vulnerability in male but not female progeny. This phenotype is likely driven by long-lasting neural adaptations within the reward neural brain pathways." @default.
- W4313477007 created "2023-01-06" @default.
- W4313477007 creator A5005668643 @default.
- W4313477007 creator A5007217803 @default.
- W4313477007 creator A5012195642 @default.
- W4313477007 creator A5013752935 @default.
- W4313477007 creator A5017805012 @default.
- W4313477007 creator A5022377573 @default.
- W4313477007 creator A5025687682 @default.
- W4313477007 creator A5030498737 @default.
- W4313477007 creator A5056521587 @default.
- W4313477007 creator A5058155742 @default.
- W4313477007 creator A5062872027 @default.
- W4313477007 creator A5071433321 @default.
- W4313477007 creator A5073019069 @default.
- W4313477007 creator A5086784121 @default.
- W4313477007 creator A5087278794 @default.
- W4313477007 creator A5088203421 @default.
- W4313477007 date "2023-01-04" @default.
- W4313477007 modified "2023-09-27" @default.
- W4313477007 title "Paternal morphine exposure enhances morphine self-administration and induces region-specific neural adaptations in reward-related brain regions of male offspring" @default.
- W4313477007 cites W193629310 @default.
- W4313477007 cites W1941089812 @default.
- W4313477007 cites W1949928978 @default.
- W4313477007 cites W1963700824 @default.
- W4313477007 cites W1966142734 @default.
- W4313477007 cites W1969966637 @default.
- W4313477007 cites W1970514775 @default.
- W4313477007 cites W1972326075 @default.
- W4313477007 cites W1973006691 @default.
- W4313477007 cites W1978805410 @default.
- W4313477007 cites W1979112369 @default.
- W4313477007 cites W1979162052 @default.
- W4313477007 cites W1982171285 @default.
- W4313477007 cites W1982407931 @default.
- W4313477007 cites W1986062308 @default.
- W4313477007 cites W1987230588 @default.
- W4313477007 cites W1989416066 @default.
- W4313477007 cites W1990456010 @default.
- W4313477007 cites W1998674360 @default.
- W4313477007 cites W2002579841 @default.
- W4313477007 cites W2003393413 @default.
- W4313477007 cites W2022667194 @default.
- W4313477007 cites W2030310872 @default.
- W4313477007 cites W2031163840 @default.
- W4313477007 cites W2035419353 @default.
- W4313477007 cites W2046996924 @default.
- W4313477007 cites W2050674567 @default.
- W4313477007 cites W2054776840 @default.
- W4313477007 cites W2056094287 @default.
- W4313477007 cites W2059632047 @default.
- W4313477007 cites W2060736945 @default.
- W4313477007 cites W2066254114 @default.
- W4313477007 cites W2066848874 @default.
- W4313477007 cites W2070187535 @default.
- W4313477007 cites W2076761282 @default.
- W4313477007 cites W2078311949 @default.
- W4313477007 cites W2085039863 @default.
- W4313477007 cites W2089169270 @default.
- W4313477007 cites W2095714216 @default.
- W4313477007 cites W2104007338 @default.
- W4313477007 cites W2114207481 @default.
- W4313477007 cites W2115725229 @default.
- W4313477007 cites W2124699909 @default.
- W4313477007 cites W2134746706 @default.
- W4313477007 cites W2137372228 @default.
- W4313477007 cites W2140252239 @default.
- W4313477007 cites W2152255570 @default.
- W4313477007 cites W2165398609 @default.
- W4313477007 cites W2166236051 @default.
- W4313477007 cites W2170250876 @default.
- W4313477007 cites W2170654934 @default.
- W4313477007 cites W2208646176 @default.
- W4313477007 cites W2310875915 @default.
- W4313477007 cites W2323909107 @default.
- W4313477007 cites W2400629514 @default.
- W4313477007 cites W2418752819 @default.
- W4313477007 cites W2530925389 @default.
- W4313477007 cites W2548448095 @default.
- W4313477007 cites W2551050667 @default.
- W4313477007 cites W2619345178 @default.
- W4313477007 cites W2734547137 @default.
- W4313477007 cites W2762894765 @default.
- W4313477007 cites W2787958667 @default.
- W4313477007 cites W2790657788 @default.
- W4313477007 cites W2793678182 @default.
- W4313477007 cites W2883702380 @default.
- W4313477007 cites W2913231589 @default.
- W4313477007 cites W2913388216 @default.
- W4313477007 cites W2988873070 @default.
- W4313477007 cites W2998972675 @default.
- W4313477007 cites W3013064929 @default.
- W4313477007 cites W3040325371 @default.
- W4313477007 cites W3146605924 @default.
- W4313477007 cites W4237795005 @default.
- W4313477007 cites W4292359598 @default.
- W4313477007 doi "https://doi.org/10.1101/2023.01.03.522600" @default.
- W4313477007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711571" @default.
- W4313477007 hasPublicationYear "2023" @default.
- W4313477007 type Work @default.