Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313477105> ?p ?o ?g. }
- W4313477105 abstract "Acetylation is a key post-translational modification (PTM) involved in the regulation of both histone and non-histone proteins. It controls cellular processes such as DNA transcription, RNA modifications, proteostasis, aging, autophagy, regulation of cytoskeletal structures, and metabolism. Acetylation is essential to maintain neuronal plasticity and therefore essential for memory and learning. Homeostasis of acetylation is maintained through the activities of histone acetyltransferases (HAT) and histone deacetylase (HDAC) enzymes, with alterations to these tightly regulated processes reported in several neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). Both hyperacetylation and hypoacetylation can impair neuronal physiological homeostasis and increase the accumulation of pathophysiological proteins such as tau, α-synuclein, and Huntingtin protein implicated in AD, PD, and HD, respectively. Additionally, dysregulation of acetylation is linked to impaired axonal transport, a key pathological mechanism in ALS. This review article will discuss the physiological roles of protein acetylation and examine the current literature that describes altered protein acetylation in neurodegenerative disorders." @default.
- W4313477105 created "2023-01-06" @default.
- W4313477105 creator A5009651038 @default.
- W4313477105 creator A5028005072 @default.
- W4313477105 creator A5058036175 @default.
- W4313477105 creator A5084569574 @default.
- W4313477105 creator A5084982961 @default.
- W4313477105 date "2023-01-04" @default.
- W4313477105 modified "2023-10-03" @default.
- W4313477105 title "The role of altered protein acetylation in neurodegenerative disease" @default.
- W4313477105 cites W1160352986 @default.
- W4313477105 cites W1482056580 @default.
- W4313477105 cites W1486762479 @default.
- W4313477105 cites W1491133549 @default.
- W4313477105 cites W1499834429 @default.
- W4313477105 cites W1509290693 @default.
- W4313477105 cites W1531585137 @default.
- W4313477105 cites W1532707293 @default.
- W4313477105 cites W1551233310 @default.
- W4313477105 cites W1583504016 @default.
- W4313477105 cites W1587321822 @default.
- W4313477105 cites W1666768116 @default.
- W4313477105 cites W1790302332 @default.
- W4313477105 cites W1876643910 @default.
- W4313477105 cites W1920542018 @default.
- W4313477105 cites W1946881562 @default.
- W4313477105 cites W1963552002 @default.
- W4313477105 cites W1963836683 @default.
- W4313477105 cites W1964044507 @default.
- W4313477105 cites W1964372470 @default.
- W4313477105 cites W1964506812 @default.
- W4313477105 cites W1965212867 @default.
- W4313477105 cites W1965296401 @default.
- W4313477105 cites W1966015199 @default.
- W4313477105 cites W1966120362 @default.
- W4313477105 cites W1966398964 @default.
- W4313477105 cites W1967890615 @default.
- W4313477105 cites W1969386224 @default.
- W4313477105 cites W1970210902 @default.
- W4313477105 cites W1970254771 @default.
- W4313477105 cites W1971925893 @default.
- W4313477105 cites W1973831249 @default.
- W4313477105 cites W1975040221 @default.
- W4313477105 cites W1975545468 @default.
- W4313477105 cites W1975692560 @default.
- W4313477105 cites W1976507388 @default.
- W4313477105 cites W1976773921 @default.
- W4313477105 cites W1976967262 @default.
- W4313477105 cites W1977471508 @default.
- W4313477105 cites W1977728966 @default.
- W4313477105 cites W1979085076 @default.
- W4313477105 cites W1979832500 @default.
- W4313477105 cites W1981549228 @default.
- W4313477105 cites W1983523416 @default.
- W4313477105 cites W1988356194 @default.
- W4313477105 cites W1989763558 @default.
- W4313477105 cites W1994189400 @default.
- W4313477105 cites W1995286508 @default.
- W4313477105 cites W1995536960 @default.
- W4313477105 cites W1995669448 @default.
- W4313477105 cites W1996888635 @default.
- W4313477105 cites W1998499089 @default.
- W4313477105 cites W1998707569 @default.
- W4313477105 cites W1999008576 @default.
- W4313477105 cites W2003189290 @default.
- W4313477105 cites W2005414132 @default.
- W4313477105 cites W2006150780 @default.
- W4313477105 cites W2006154315 @default.
- W4313477105 cites W2008549312 @default.
- W4313477105 cites W2008589789 @default.
- W4313477105 cites W2009826707 @default.
- W4313477105 cites W2011634611 @default.
- W4313477105 cites W2012034410 @default.
- W4313477105 cites W2012887006 @default.
- W4313477105 cites W2017881592 @default.
- W4313477105 cites W2019050557 @default.
- W4313477105 cites W2019656833 @default.
- W4313477105 cites W2019845642 @default.
- W4313477105 cites W2020186556 @default.
- W4313477105 cites W2021098795 @default.
- W4313477105 cites W2023265973 @default.
- W4313477105 cites W2023577211 @default.
- W4313477105 cites W2026627428 @default.
- W4313477105 cites W2026674733 @default.
- W4313477105 cites W2028597345 @default.
- W4313477105 cites W2029130907 @default.
- W4313477105 cites W2029399678 @default.
- W4313477105 cites W2030795821 @default.
- W4313477105 cites W2032307875 @default.
- W4313477105 cites W2033324724 @default.
- W4313477105 cites W2034748898 @default.
- W4313477105 cites W2038320708 @default.
- W4313477105 cites W2038557487 @default.
- W4313477105 cites W2039313004 @default.
- W4313477105 cites W2040462263 @default.
- W4313477105 cites W2040773347 @default.
- W4313477105 cites W2040773899 @default.
- W4313477105 cites W2041959419 @default.
- W4313477105 cites W2042586741 @default.
- W4313477105 cites W2045489211 @default.