Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313477359> ?p ?o ?g. }
- W4313477359 abstract "Abstract Aim Recruitment of renal functional reserve (RFR) with amino acid loading increases renal blood flow and glomerular filtration rate. However, its effects on renal cortical and medullary oxygenation have not been determined. Accordingly, we tested the effects of recruitment of RFR on renal cortical and medullary oxygenation in non‐anesthetized sheep. Methods Under general anesthesia, we instrumented 10 sheep to enable subsequent continuous measurements of systemic and renal hemodynamics, renal oxygen delivery and consumption, and cortical and medullary tissue oxygen tension (PO 2 ). We then measured the effects of recruitment of RFR with an intravenous infusion of 500 ml of a clinically used amino acid solution (10% Synthamin® 17) in the non‐anesthetized state. Results Compared with baseline, Synthamin® 17 infusion significantly increased renal oxygen delivery mean ± SD maximum increase: (from 0.79 ± 0.17 to 1.06 ± 0.16 ml/kg/min, p < 0.001), renal oxygen consumption (from 0.08 ± 0.01 to 0.15 ± 0.02 ml/kg/min, p < 0.001), and glomerular filtration rate (+45.2 ± 2.7%, p < 0.001). Renal cortical tissue PO 2 increased by a maximum of 26.4 ± 1.1% ( p = 0.001) and medullary tissue PO 2 increased by a maximum of 23.9 ± 2.8% ( p = 0. 001). Conclusions In non‐anesthetized healthy sheep, recruitment of RFR improved renal cortical and medullary oxygenation. These observations might have implications for the use of recruitment of RFR for diagnostic and therapeutic purposes." @default.
- W4313477359 created "2023-01-06" @default.
- W4313477359 creator A5005567942 @default.
- W4313477359 creator A5011216396 @default.
- W4313477359 creator A5012270101 @default.
- W4313477359 creator A5026900739 @default.
- W4313477359 creator A5029550266 @default.
- W4313477359 creator A5045230003 @default.
- W4313477359 creator A5058744980 @default.
- W4313477359 creator A5087217319 @default.
- W4313477359 date "2023-01-12" @default.
- W4313477359 modified "2023-10-14" @default.
- W4313477359 title "The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non‐anesthetized sheep" @default.
- W4313477359 cites W1538633038 @default.
- W4313477359 cites W1948021223 @default.
- W4313477359 cites W1972205279 @default.
- W4313477359 cites W1976842654 @default.
- W4313477359 cites W1978482615 @default.
- W4313477359 cites W1979594545 @default.
- W4313477359 cites W1986659573 @default.
- W4313477359 cites W1987380508 @default.
- W4313477359 cites W1993326705 @default.
- W4313477359 cites W1996134742 @default.
- W4313477359 cites W2005792121 @default.
- W4313477359 cites W2006153373 @default.
- W4313477359 cites W2010536286 @default.
- W4313477359 cites W2015757745 @default.
- W4313477359 cites W2017823130 @default.
- W4313477359 cites W2021888762 @default.
- W4313477359 cites W2021985651 @default.
- W4313477359 cites W2028990184 @default.
- W4313477359 cites W2030715519 @default.
- W4313477359 cites W2032273917 @default.
- W4313477359 cites W2033012123 @default.
- W4313477359 cites W2034242281 @default.
- W4313477359 cites W2046152126 @default.
- W4313477359 cites W2047502519 @default.
- W4313477359 cites W2054438006 @default.
- W4313477359 cites W2059596972 @default.
- W4313477359 cites W2065753330 @default.
- W4313477359 cites W2075882775 @default.
- W4313477359 cites W2084972347 @default.
- W4313477359 cites W2088125353 @default.
- W4313477359 cites W2091882459 @default.
- W4313477359 cites W2098710062 @default.
- W4313477359 cites W2119592801 @default.
- W4313477359 cites W2123841491 @default.
- W4313477359 cites W2131973068 @default.
- W4313477359 cites W2134181694 @default.
- W4313477359 cites W2140919744 @default.
- W4313477359 cites W2156486561 @default.
- W4313477359 cites W2163520934 @default.
- W4313477359 cites W2172378076 @default.
- W4313477359 cites W2180745593 @default.
- W4313477359 cites W2216485875 @default.
- W4313477359 cites W2249931637 @default.
- W4313477359 cites W2314209899 @default.
- W4313477359 cites W2340383377 @default.
- W4313477359 cites W2400965286 @default.
- W4313477359 cites W2435143216 @default.
- W4313477359 cites W2463008436 @default.
- W4313477359 cites W2463479552 @default.
- W4313477359 cites W2768945313 @default.
- W4313477359 cites W2788251575 @default.
- W4313477359 cites W2885857919 @default.
- W4313477359 cites W2889216614 @default.
- W4313477359 cites W2897036418 @default.
- W4313477359 cites W2904773592 @default.
- W4313477359 cites W2911149341 @default.
- W4313477359 cites W2960604584 @default.
- W4313477359 cites W3016060442 @default.
- W4313477359 cites W3036487583 @default.
- W4313477359 cites W3047512041 @default.
- W4313477359 cites W3092998304 @default.
- W4313477359 cites W3211723552 @default.
- W4313477359 cites W4214573408 @default.
- W4313477359 cites W4225989335 @default.
- W4313477359 cites W4253545088 @default.
- W4313477359 cites W8054040 @default.
- W4313477359 cites W84559639 @default.
- W4313477359 cites W897246557 @default.
- W4313477359 cites W2049899442 @default.
- W4313477359 doi "https://doi.org/10.1111/apha.13919" @default.
- W4313477359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598336" @default.
- W4313477359 hasPublicationYear "2023" @default.
- W4313477359 type Work @default.
- W4313477359 citedByCount "1" @default.
- W4313477359 countsByYear W43134773592023 @default.
- W4313477359 crossrefType "journal-article" @default.
- W4313477359 hasAuthorship W4313477359A5005567942 @default.
- W4313477359 hasAuthorship W4313477359A5011216396 @default.
- W4313477359 hasAuthorship W4313477359A5012270101 @default.
- W4313477359 hasAuthorship W4313477359A5026900739 @default.
- W4313477359 hasAuthorship W4313477359A5029550266 @default.
- W4313477359 hasAuthorship W4313477359A5045230003 @default.
- W4313477359 hasAuthorship W4313477359A5058744980 @default.
- W4313477359 hasAuthorship W4313477359A5087217319 @default.
- W4313477359 hasBestOaLocation W43134773591 @default.
- W4313477359 hasConcept C126322002 @default.
- W4313477359 hasConcept C142225936 @default.