FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313477416> ?p ?o ?g. }

• W4313477416 abstract "Background The immune activation caused by microbial translocation has been considered to be a major driver of HIV infection progression. The dysbiosis of gut microbiota has been demonstrated in HIV infection, but the interplay between gut microbiota and its metabolites in the pathogenesis of HIV is seldom reported. Methods We conducted a case-controlled study including 41 AIDS patients, 39 pre-AIDS patients and 34 healthy controls. Both AIDS group and pre-AIDS group were divided according to clinical manifestations and CD4 + T cell count. We collected stool samples for 16S rDNA sequencing and untargeted metabolomics analysis, and examined immune activation and microbial translocation for blood samples. Results The pre-AIDS and AIDS groups had higher levels of microbial translocation and immune activation. There were significant differences in gut microbiota and metabolites at different stages of HIV infection. Higher abundances of pathogenic bacteria or opportunistic pathogen, as well as lower abundances of butyrate-producing bacteria and bacteria with anti-inflammatory potential were associated with HIV severity. The metabolism of tryptophan was disordered after HIV infection. Lower level of anti-inflammatory metabolites and phosphonoacetate, and higher level of phenylethylamine and polyamines were observed in HIV infection. And microbial metabolic pathways related to altered metabolites differed. Moreover, disrupted metabolites contributed by altered microbiota were found to be correlated to microbial translocation and immune activation. Conclusions Metabolites caused by dysbiosis of gut microbiota and related metabolic function are correlated to immune activation and microbial translocation, suggesting that the effect of microbiota on metabolites is related to intestinal barrier disruption in HIV infection." @default.
• W4313477416 created "2023-01-06" @default.
• W4313477416 creator A5013973657 @default.
• W4313477416 creator A5026727930 @default.
• W4313477416 creator A5029741432 @default.
• W4313477416 creator A5031888627 @default.
• W4313477416 creator A5032787375 @default.
• W4313477416 creator A5039933653 @default.
• W4313477416 creator A5040878586 @default.
• W4313477416 creator A5043079879 @default.
• W4313477416 creator A5044241996 @default.
• W4313477416 creator A5048603687 @default.
• W4313477416 creator A5055212155 @default.
• W4313477416 creator A5059212207 @default.
• W4313477416 creator A5059230831 @default.
• W4313477416 creator A5060345917 @default.
• W4313477416 creator A5071773009 @default.
• W4313477416 creator A5073064156 @default.
• W4313477416 creator A5081311272 @default.
• W4313477416 date "2023-01-04" @default.
• W4313477416 modified "2023-09-29" @default.
• W4313477416 title "The altered metabolites contributed by dysbiosis of gut microbiota are associated with microbial translocation and immune activation during HIV infection" @default.
• W4313477416 cites W1563943938 @default.
• W4313477416 cites W1994287107 @default.
• W4313477416 cites W1999388037 @default.
• W4313477416 cites W2000063753 @default.
• W4313477416 cites W2000473473 @default.
• W4313477416 cites W2016488838 @default.
• W4313477416 cites W2017614891 @default.
• W4313477416 cites W2037505073 @default.
• W4313477416 cites W2052432894 @default.
• W4313477416 cites W2064304477 @default.
• W4313477416 cites W2072544855 @default.
• W4313477416 cites W2072974354 @default.
• W4313477416 cites W2089271034 @default.
• W4313477416 cites W2091961926 @default.
• W4313477416 cites W2095050873 @default.
• W4313477416 cites W2097515723 @default.
• W4313477416 cites W2122483069 @default.
• W4313477416 cites W2136957906 @default.
• W4313477416 cites W2140573695 @default.
• W4313477416 cites W2147024250 @default.
• W4313477416 cites W2147825765 @default.
• W4313477416 cites W2147856029 @default.
• W4313477416 cites W2149492547 @default.
• W4313477416 cites W2150484278 @default.
• W4313477416 cites W2192708377 @default.
• W4313477416 cites W2212811500 @default.
• W4313477416 cites W2296527675 @default.
• W4313477416 cites W2323471282 @default.
• W4313477416 cites W2324892320 @default.
• W4313477416 cites W2337536067 @default.
• W4313477416 cites W2345060140 @default.
• W4313477416 cites W2401783292 @default.
• W4313477416 cites W2417926799 @default.
• W4313477416 cites W2418340564 @default.
• W4313477416 cites W2524137744 @default.
• W4313477416 cites W2548186413 @default.
• W4313477416 cites W2564655577 @default.
• W4313477416 cites W2565100337 @default.
• W4313477416 cites W2575971715 @default.
• W4313477416 cites W2579549256 @default.
• W4313477416 cites W2588845501 @default.
• W4313477416 cites W2747205287 @default.
• W4313477416 cites W2760507388 @default.
• W4313477416 cites W2772847295 @default.
• W4313477416 cites W2789740507 @default.
• W4313477416 cites W2791453800 @default.
• W4313477416 cites W2791806416 @default.
• W4313477416 cites W2795720999 @default.
• W4313477416 cites W2803783024 @default.
• W4313477416 cites W2804621837 @default.
• W4313477416 cites W2904159701 @default.
• W4313477416 cites W2914347937 @default.
• W4313477416 cites W2930937740 @default.
• W4313477416 cites W2938785635 @default.
• W4313477416 cites W2947074052 @default.
• W4313477416 cites W2955147700 @default.
• W4313477416 cites W2959946736 @default.
• W4313477416 cites W2963624414 @default.
• W4313477416 cites W2968350563 @default.
• W4313477416 cites W2969960763 @default.
• W4313477416 cites W2975934993 @default.
• W4313477416 cites W2977433364 @default.
• W4313477416 cites W2980856999 @default.
• W4313477416 cites W2982576856 @default.
• W4313477416 cites W2983525293 @default.
• W4313477416 cites W2990926752 @default.
• W4313477416 cites W2991645484 @default.
• W4313477416 cites W2997452679 @default.
• W4313477416 cites W2999539828 @default.
• W4313477416 cites W3006102400 @default.
• W4313477416 cites W3012048900 @default.
• W4313477416 cites W3084270303 @default.
• W4313477416 cites W3084436257 @default.
• W4313477416 cites W3088175567 @default.
• W4313477416 cites W3109419522 @default.
• W4313477416 cites W3111651237 @default.
• W4313477416 cites W3160985962 @default.
• W4313477416 cites W3203086298 @default.

• next