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• W4313478038 endingPage "151695" @default.
• W4313478038 startingPage "151695" @default.
• W4313478038 abstract "Necrotizing enterocolitis (NEC) is the leading cause of death and disability from gastrointestinal disease in premature infants. The mortality of patients with NEC is approximately 30%, a figure that has not changed in many decades, reflecting the need for a greater understanding of its pathogenesis. Progress towards understanding the cellular and molecular mechanisms underlying NEC requires the study of highly translational animal models. Such animal models must mimic the biology and physiology of premature infants, while still allowing for safe experimental manipulation of environmental and microbial factors thought to be associated with the risk and severity of NEC. Findings from animal models have yielded insights into the interactions between the host, the colonizing microbes, and the innate immune receptor Toll-like Receptor 4 (TLR4) in driving disease development. This review discusses the relative strengths and weaknesses of available in vivo, in vitro, and NEC-in-a-dish models of this disease. We also highlight the unique contributions that each model has made to our understanding of the complex interactions between enterocytes, microbiota, and immune cells in the pathogenesis of NEC. The overall purpose of this review is to provide a menu of options regarding currently available animal models of NEC, while in parallel hopefully reducing the potential uncertainty and confusion regarding NEC models to assist those who wish to enter this field from other disciplines." @default.
• W4313478038 created "2023-01-06" @default.
• W4313478038 creator A5007004393 @default.
• W4313478038 creator A5024080747 @default.
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• W4313478038 creator A5040478162 @default.
• W4313478038 creator A5042211554 @default.
• W4313478038 creator A5051111207 @default.
• W4313478038 creator A5083298871 @default.
• W4313478038 date "2023-02-01" @default.
• W4313478038 modified "2023-09-26" @default.
• W4313478038 title "Models of necrotizing enterocolitis" @default.
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